Consistency of Automated Neuropsychological Assessment Metrics (ANAM) Performance in Those With Deployment Acquired Mild Traumatic Brain Injury (TBI)



Status:Completed
Conditions:Hospital, Neurology
Therapuetic Areas:Neurology, Other
Healthy:No
Age Range:18 - 45
Updated:4/21/2016
Start Date:February 2011
End Date:January 2016

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Consistency of ANAM Performance in Those With Deployment Acquired Mild TBI

The purpose of this project is to explore the degree to which performance consistency on
neuropsychological measures varies in a sample of Operation Iraqi Freedom (OIF)/Operation
Enduring Freedom (OEF) Veterans with a history of mild traumatic brain injury (mTBI) with
persistent self-reported symptoms.

Mild TBI outcome studies are traditionally limited to single administration or
baseline/post-injury assessment models and they often fail to show enduring deficits among
persons complaining of such problems. It may be the case that our standard approach to
deficit measurement in mTBI has confounded our ability to elicit the actual impairment. The
proposed study could generate an assessment paradigm shift (performance over time) and
afford professionals the direction to better assess and ultimately serve persons with mTBI.
Additionally, research on the impact of PTSD symptoms on throughput and cognitive
performance has been mixed (Bremner et al., 1995; Brenner et al, 2010; Vasterling et al.,
1998, 2002, 2006) and the proposed study will yield additional data in that area.

Inclusion Criteria:

- Between the ages of 18-45 years old

- At least one OEF/OIF deployment

- Currently receiving physical and/or mental health care through the VA Eastern
Colorado Health Care System

- For TBI group - veteran must have a history of at least one deployment- related mild
TBI with persistent symptoms

Exclusion Criteria:

- Effortful performance on the Test of Memory Malingering (TOMM)

- History of other significant neurological disease (other than mild TBI for the
appropriate group) as assessed by interview and chart review

- History or diagnosis of deployment-related moderate or severe TBI or mild TBI without
persistent symptoms for the TBI groups, or any history of deployment-related TBI for
the non-TBI group, as assessed by interview and chart review

- History or diagnosis of non-deployment-related TBI

- Diagnosis of Schizophrenia or Bipolar Mood DisorderI Disorder as assessed by
interview and/or chart review.

- Problematic drinking behavior that consistently exceeds recommended drinking limits
per day, e.g., Diagnosis of Alcohol Abuse Disorder or Alcohol Dependence Disorder per
the MINI; or five or more alcoholic drinks per day, four out of seven days per week
for the previous two weeks or during the assessment process

- Use of illicit substance(s) more than five times in the two weeks before enrollment
or during the testing process.

- Inability to read the informed consent document or adequately respond to questions
regarding the informed consent procedure
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