Phase I Clinical Trial to Evaluate the Safety, Pharmacokinetics and Efficacy of CW002

Neuromuscular blocking agents are especially important in intubation (insertion of breathing
tube into the windpipe) because a quick and effective muscle block is needed to promptly
complete the process and secure the airway. In addition, being able to rapidly reverse a
blocking agent is desirable so that the patient can breathe on his/her own as soon as
possible.

Inclusion Criteria:

- Is male or female in good health (ASA I) between the ages of 18 and 49 years
inclusive, with no concurrent disease or illness. Females must be non pregnant, non
lactating, and practicing an acceptable method of birth control (e.g., barrier, oral
contraceptive, vasectomized partner, abstinence) or be surgically sterile or post
menopausal. A pregnancy test will be performed at Screening and on Day 1 to confirm
non-pregnant status of female subjects.

- Weighs between 55 and 95 kg, inclusive, and has a body mass index (BMI) between 18
and 30 kg/m2 (BMI calculated as weight in kg/[height in m]2 )

- Agrees to abstain from taking any dietary supplements or non-prescription drugs
(except for multivitamins or as authorized by the Investigator and Medical Monitor)
for 3 days prior to Baseline through Follow-Up

- Agrees to abstain from taking any prescription drugs (except as authorized by the
Investigator and Medical Monitor) during the 14 days prior to Baseline through
Follow-Up

- Agrees to abstain from consuming alcohol-containing beverages for 3 days prior to
Baseline through Follow-up

- Is in good health (ASA Class I) based on medical history and clinically acceptable
results on the following assessments: physical examination, vital signs, 12 lead
ECG, clinical chemistry, hematology/coagulation, and urinalysis. Seated systolic BP
must be > 90 mmHg and ≤ 140 mmHg and seated diastolic BP must be > 50 mmHg and ≤ 90
mmHg at Screening and Baseline

- Has no history of cardiovascular, pulmonary, renal, hepatic, central nervous system,
or neuromuscular disease, or history of asthma or diabetes (ASA Class I)

- Is able to communicate effectively with study personnel and is considered reliable,
willing, and cooperative in terms of compliance with the protocol requirements

- Voluntarily gives written informed consent to participate in the study

- Has available a responsible adult who has agreed to transport the subject home

Exclusion Criteria:

- Has any current acute or chronic disease

- Has a history of any clinically important medical disorder including any of the
following: cardiovascular, pulmonary, hepatic, renal, CNS or neuromuscular disease,
asthma or diabetes

- Has a history of anaphylaxis, a documented hypersensitivity reaction, or a clinically
important idiosyncratic reaction to any drug

- Has a history of neuromuscular junction disease (e.g., myotonic dystrophy, polio,
myasthenia gravis, botulism poisoning)

- Has a history of malignant hyperthermia

- Has had recent (within 2 weeks) use of aminoglycoside antibiotics or corticosteroids

- Has a history of sleep apnea

- Has a history of prior anesthetic complications

- Has any history of asthma requiring management for reactive airway disease

- Has a history of an anatomic airway abnormality or indication of an airway
abnormality assessed during the Screening airway examination that could interfere
with laryngoscopy or tracheal intubation

- Has a history of Human Immunodeficiency Virus (HIV) infection or Acquired Immune
Deficiency Syndrome (AIDS), or has a history of viral hepatitis (other than Hepatitis
A)

- Has a history of malignancy within the past 5 years, with the exception of
successfully treated non-metastatic basal cell or squamous cell carcinomas of the
skin and/or localized carcinoma in situ of the cervix

- Has a predisposing condition that could interfere with the absorption, distribution,
metabolism, or excretion of drugs or any condition that may confound the PK analyses,
particularly hepatic or renal disease

- Has received another investigational drug within 30 days prior to the Screening Visit

- Has a history of alcohol abuse (regularly drinks more than 4 units of alcohol per
day; 1 unit = ½ pint of beer, 1 glass of wine, or 1 ounce of spirit) and/or evidence
of any use within 3 days prior to Baseline

- Has a history or current evidence of abuse of licit or illicit drug substances or a
positive urine drug screen for drugs of abuse

- Currently uses tobacco-containing products or has a history of tobacco use within 6
months prior to the Screening Visit

- Has donated blood or plasma within 60 days prior to the Screening Visit

- Has an abnormal bleeding tendency