Clinical And Economic Impact Of Upfront Plerixafor In Autologous Transplantation
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Blood Cancer, Lymphoma, Hematology |
| Therapuetic Areas: | Hematology, Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | April 2011 |
| End Date: | July 2016 |
This protocol will investigate the effectiveness of plerixafor in the up-front setting in
avoiding a second round of mobilization and whether this translates into a clinical and
economic benefit.
avoiding a second round of mobilization and whether this translates into a clinical and
economic benefit.
Peripheral blood stem cells are now considered the standard source of stem cells for
autologous stem cell transplants. Unfortunately, there is still a 20-30% chance that
inadequate numbers of stem cells will be collected, resulting in prolonged recovery of cell
counts after transplantation and increased transfusion dependence. There is also a
significant economic burden associated with remobilization and a risk that delays in
collecting sufficient numbers of stem cells can result in an increased chance of disease
recurrence prior to transplantation.
autologous stem cell transplants. Unfortunately, there is still a 20-30% chance that
inadequate numbers of stem cells will be collected, resulting in prolonged recovery of cell
counts after transplantation and increased transfusion dependence. There is also a
significant economic burden associated with remobilization and a risk that delays in
collecting sufficient numbers of stem cells can result in an increased chance of disease
recurrence prior to transplantation.
Inclusion Criteria:
- Patients with multiple myeloma or non-Hodgkin's lymphoma with a planned autologous
transplant and who are eligible for peripheral stem cell mobilization.
- Karnofsky Performance Status ≥ 70.
- Age ≥ 18
- Less than 30% involvement of marrow with disease.
Exclusion Criteria:
- > 30% marrow involvement with disease
- Age < 18.
- Pregnant women.
We found this trial at
1
site
Click here to add this to my saved trials
