More Frequent In-Center Hemodialysis in Pediatric End Stage Renal Disease
| Status: | Completed |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | 3 - 21 |
| Updated: | 12/28/2013 |
| Start Date: | March 2011 |
| End Date: | August 2013 |
| Contact: | Benjamin L Laskin, MD |
| Email: | benjamin.laskin@cchmc.org |
| Phone: | 513-636-4531 |
A Pilot Study of More Frequent In-Center Hemodialysis to Improve Outcomes in Pediatric End Stage Renal Disease
A health kidney works 24 hours a day, 7 days a week to remove toxins and fluid from the
body. Many children with permanent kidney failure undergo dialysis, a life saving procedure
that takes the place of a kidney. Currently, many children with permanent kidney failure
only receive dialysis treatments 3 days a week in the hospital dialysis clinic. Children on
dialysis have a markedly reduced life expectancy, with a life span 40-50 years shorter than
their healthy counterparts. Survival for these children has not improved over the last 20
years. These data indicate that the current dialysis treatment strategy is unacceptable.
This research project will study if more frequent dialysis, performed 5 days per week, will
improve the health of children with permanent kidney failure compared to the current
treatment strategy. Children will be treated with both traditional and more frequent
dialysis schedules to measure improvements in their health and well being.
body. Many children with permanent kidney failure undergo dialysis, a life saving procedure
that takes the place of a kidney. Currently, many children with permanent kidney failure
only receive dialysis treatments 3 days a week in the hospital dialysis clinic. Children on
dialysis have a markedly reduced life expectancy, with a life span 40-50 years shorter than
their healthy counterparts. Survival for these children has not improved over the last 20
years. These data indicate that the current dialysis treatment strategy is unacceptable.
This research project will study if more frequent dialysis, performed 5 days per week, will
improve the health of children with permanent kidney failure compared to the current
treatment strategy. Children will be treated with both traditional and more frequent
dialysis schedules to measure improvements in their health and well being.
Inclusion Criteria:
- Current outpatient ESRD pediatric patients, 3-21 years old, receiving in-center
chronic HD.
- Patients have to be on chronic HD for at least 2 months before eligibility
Exclusion Criteria:
- Patients with a scheduled (with a specific transplant date) kidney transplant in the
next 6 months
- Patients scheduled to be switched to peritoneal dialysis in the next 6 months
- Patients currently receiving >3 days per week of hemodialysis
- Patients currently receiving >12 hours per week of hemodialysis
- Anyone <3 years of age would be excluded from the study, so our minimum anticipated
patient weight would be about 11 kg
- Patients >21 years of age at enrollment
- Patients receiving concomitant peritoneal dialysis
- Patients with <2 months on chronic HD
- Patients with a temporary or femoral dialysis catheter
- Patients who are not hypertensive (both not on blood pressure medication and with a
SBP <95th percentile for age, sex, and height)
- Patients enrolled in an investigational drug trial involving blood pressure
medication or any other clinical trial potentially affecting the primary outcome of
the study
Patients listed for a deceased donor transplant will not be excluded.
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