Platelet Function Monitoring in Patients With Acute Myocardial Infarction

Inclusion Criteria:

- Patient >18 years old.

- Patient scheduled to undergo PCI for either stable CAD or AMI:

- Stable CAD defined as negative cardiac isoenzymes prior to the PCI as well as no
resting ECG changes indicative of ACS.

- AMI defined as positive cardiac isoenzymes prior to the PCI and/or resting ECG
changes indicative of ACS.

3. Patients treated with a loading dose of clopidogrel at least 6 hours prior to the
blood draw or on a maintenance dose of clopidogrel (of at least 75mg QD) for a
minimum of 5 days.

Exclusion Criteria:

- Known allergies to aspirin, clopidogrel, or prasugrel

- Use of a glycoprotein (GP) IIb/IIIa inhibitor within 8 hours of the blood draw;

- Patient known to be pregnant or lactating;

- Patient with known history of bleeding diathesis or currently active bleeding;

- Platelet count <100,000/mm the day of the blood draw;

- Hematocrit <25% the day of the blood draw;

- On warfarin therapy at the time of the blood draw or the need for warfarin therapy in
the subsequent month following the blood draw;

- Known blood transfusion within the preceding 10 days of the blood draw;

- Patient who has received NSAID (not including ASA) within preceding 24 hours of the
blood draw;

- Patients presenting with cardiogenic shock;

- Any significant medical condition, which in the investigator's opinion may interfere
with the patient's optimal participation in the study.