Costimulatory Molecules as Biomarkers in Cystic Fibrosis
| Status: | Completed |
|---|---|
| Conditions: | Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/2/2016 |
| Start Date: | July 2011 |
| End Date: | June 2013 |
| Contact: | Jeffrey A Gold, MD |
| Email: | goldje@ohsu.edu |
| Phone: | 5034181496 |
The purpose of this study is to investigate the expression of a certain class of molecules,
called costimulatory molecules, in humans with Cystic Fibrosis. Cystic Fibrosis is a genetic
disorder which renders the lung susceptible to persistent inflammation which, at times, can
worsen, resulting in accelerated decline in lung function and eventually death or
transplant. Our goal is to determine if the levels of costimulatory markers can be used to
predict exacerbation and subsequent lung function decline in subjects with Cystic Fibrosis.
called costimulatory molecules, in humans with Cystic Fibrosis. Cystic Fibrosis is a genetic
disorder which renders the lung susceptible to persistent inflammation which, at times, can
worsen, resulting in accelerated decline in lung function and eventually death or
transplant. Our goal is to determine if the levels of costimulatory markers can be used to
predict exacerbation and subsequent lung function decline in subjects with Cystic Fibrosis.
Inclusion Criteria:
- Willingness to participate
Exclusion Criteria:
- Presence of HIV
- Presence of Lymphoma/Leukemia
- Presence of Lung or other solid organ Transplant
- Pregnancy
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