Effect of Vitamin D Repletion on Insulin Resistance and Systemic Inflammation
| Status: | Completed |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 21 - 65 |
| Updated: | 12/5/2018 |
| Start Date: | March 2009 |
| End Date: | March 2015 |
The purpose of this research is to study the effects of Vitamin D supplementation on the
body's response to insulin (a hormone that controls blood sugar), on inflammation and/or on
specific cells and processes in fat tissue, and on function of skeletal muscle and joints.
body's response to insulin (a hormone that controls blood sugar), on inflammation and/or on
specific cells and processes in fat tissue, and on function of skeletal muscle and joints.
Over the last several years, studies have shown that low vitamin D levels may increase risk
of development of Type 2 Diabetes. The investigators will administer vitamin D3
(Cholecalciferol) to nondiabetic, insulin resistant subjects with vitamin D deficiency (total
vitamin D levels < 20 ng/ml) to increase the level of vitamin D initially to 30-50ng/ml and
then to higher normal range of 51-75 ng/ml. The investigators will study its effects on
insulin action, adipose tissue inflammation, and musculoskeletal function.
of development of Type 2 Diabetes. The investigators will administer vitamin D3
(Cholecalciferol) to nondiabetic, insulin resistant subjects with vitamin D deficiency (total
vitamin D levels < 20 ng/ml) to increase the level of vitamin D initially to 30-50ng/ml and
then to higher normal range of 51-75 ng/ml. The investigators will study its effects on
insulin action, adipose tissue inflammation, and musculoskeletal function.
Inclusion Criteria:
- Age 21-65 years old
- Serum 25(OH)D<20ng/ml
- Insulin Resistant based on HOMA-IR score of >3
- Able and willing to provide informed consent
- BMI 25-39
- For T2DM: A1c between 7.5 and 9.5
Exclusion Criteria:
- FPG greater than or equal to 126 mg/dl or 2-hour-OGTT plasma glucose greater than or
equal to 200 mg/dl
- HIV/AIDS
- History of any cancer
- Sarcoidosis
- Alcohol or substance abuse
- Cushing's syndrome
- Primary hyperparathyroidism
- Nephrolithiasis
- Pregnancy or breastfeeding
- Regular visits to a tanning salon
- Hypercalcemia or hypocalcemia
- Untreated or uncontrolled hypertension
- Any chronic illness requiring medication, other than arthritis, hypertension and
hyperlipidemia
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