Dornase Alfa Therapy for Ventilator Associated Lung Infections in the Neonatal Intensive Care Unit (NICU)
| Status: | Completed |
|---|---|
| Conditions: | Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 8/9/2018 |
| Start Date: | May 2011 |
| End Date: | April 30, 2017 |
Pilot Study of Dornase Alfa (Pulmozyme) Therapy for Acquired Ventilator Associated Infection in Preterm and Late Preterm Infants in the Neonatal Intensive Care Unit
To evaluate the effect of Dornase alfa on preterm and late preterm neonates with ventilator
associated pulmonary infections. Dornase alfa has been effective in the treatment of
pulmonary infections in patients with cystic fibrosis by aiding mucus clearance. The bacteria
causing pulmonary infections in cystic fibrosis patients is similar to those infecting
preterm infants. The investigators expect that dornase alfa therapy will improve recovery
from ventilator associated pulmonary infections in preterm infants.
associated pulmonary infections. Dornase alfa has been effective in the treatment of
pulmonary infections in patients with cystic fibrosis by aiding mucus clearance. The bacteria
causing pulmonary infections in cystic fibrosis patients is similar to those infecting
preterm infants. The investigators expect that dornase alfa therapy will improve recovery
from ventilator associated pulmonary infections in preterm infants.
Inclusion Criteria:
- infants less than 38 weeks gestation and over 7 days of age
- infants with a ventilator associated pulmonary infection, defined as intubated infants
who have moderate to heavy White Blood Cells (WBCs) on tracheal aspirate, organisms on
tracheal aspirate gram stain, a positive endotracheal tube culture, a chest x-ray with
infiltrate, consolidation or atelectasis, an increase in oxygen (FiO2) requirement and
whom the clinical team decides to treat with systemic antibiotic therapy
Exclusion Criteria:
- Extremely ill infants not expected to survive
- Critically ill infants requiring high frequency ventilation
- Infants with congenital pneumonia
- Infants with congenital malformations of the respiratory system (e.g. Congenital
diaphragmatic hernia, cystic adenomatoid malformation or tracheo-esophageal fistula)
Cyanotic congenital heart disease, chromosomal abnormalities and infants with a
positive newborn screen for cystic fibrosis
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3800 Reservoir Rd NW
Washington, District of Columbia 20007
Washington, District of Columbia 20007
(202) 444-2000
Georgetown University Hospital MedStar Georgetown University Hospital is a not-for-profit, acute-care teaching and research hospital...
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