Role of Immune Activation in Response of Head and Neck Squamous Cell Carcinoma to Therapy
| Status: | Completed |
|---|---|
| Conditions: | Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases, Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 5/3/2014 |
| Start Date: | October 2010 |
| End Date: | December 2012 |
| Contact: | Rachel Abbott |
| Email: | Rachel.Abbott@mssm.edu |
| Phone: | 212-824-7337 |
Biomarkers of Immune Function as Predictors of Head and Neck Squamous Cell Carcinoma (HNSCC) in Response to Therapy
The purpose of this study is to investigate the role of the immune system in the response of
squamous cell cancers of the head and neck to treatment that includes radiation therapy.
Current research demonstrates that several natural immune cells and molecules affect the way
the body's immune system interacts with a cancerous growth. Some cancers may be related to
infection with a virus, such as the Human Papilloma Virus (HPV). Studying the activity of
the immune system in head and neck cancers, especially cancers related to HPV infections,
can provide valuable information to better understand the body's interaction with cancer
cells.
squamous cell cancers of the head and neck to treatment that includes radiation therapy.
Current research demonstrates that several natural immune cells and molecules affect the way
the body's immune system interacts with a cancerous growth. Some cancers may be related to
infection with a virus, such as the Human Papilloma Virus (HPV). Studying the activity of
the immune system in head and neck cancers, especially cancers related to HPV infections,
can provide valuable information to better understand the body's interaction with cancer
cells.
This is a study of the immune response in patients with oropharyngeal cancer who undergo
treatment with radiation, chemoradiation, or robotic surgery. Many oropharyngeal cancers
are caused by infection with the human Papillomavirus (HPV), and patients with HPV-mediated
tumors have much better prognosis and treatment response compared to patients with
HPV-negative tumors. The investigators will test the hypothesis that radiation-based
therapy of oropharyngeal cancer is associated with activation of the endogenous HPV-specific
immune response. In this study the investigators will collect blood at several time points
before, during, and after treatment to monitor the immune response in patients with tumors
positive and negative for HPV versus normal healthy volunteers.
treatment with radiation, chemoradiation, or robotic surgery. Many oropharyngeal cancers
are caused by infection with the human Papillomavirus (HPV), and patients with HPV-mediated
tumors have much better prognosis and treatment response compared to patients with
HPV-negative tumors. The investigators will test the hypothesis that radiation-based
therapy of oropharyngeal cancer is associated with activation of the endogenous HPV-specific
immune response. In this study the investigators will collect blood at several time points
before, during, and after treatment to monitor the immune response in patients with tumors
positive and negative for HPV versus normal healthy volunteers.
Inclusion Criteria:
- The patient has biopsy-proven squamous cell carcinoma, Stage II-IV, of the oropharynx
or larynx.
- The patient is to undergo treatment with radiation, chemo-radiation, or robotic
surgery.
- The patient is able to give informed consent.
- The patient is at least 18 years old.
- The patient's ECOG performance status is
Exclusion Criteria:
- The patient has had prior head and neck squamous cell carcinoma, with the exception
of superficial cutaneous basal cell or squamous cell carcinomas.
- The patient has active cancer in another part of the body, with the exception of
superficial cutaneous basal cell or squamous cell carcinomas.
- If a cancer survivor, the disease free interval is less than 5 years, with the
exception of superficial cutaneous basal cell or squamous cell carcinomas.
- The patient is a minor.
- The patient is pregnant.
- The patient is a prisoner.
- The patient is incapable of understanding the consent process.
- The patient has previously received definitive surgical, radiation, or chemoradiation
treatment for HNSCC.
- The patient has a history of HIV or other known cause of immunosuppression, or is
actively taking immunosuppressive medications due to organ transplantation,
rheumatoid disease, or other medical conditions.
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