ARCHER 1009 : A Study Of Dacomitinib (PF-00299804) Vs. Erlotinib In The Treatment Of Advanced Non-Small Cell Lung Cancer



Status:Completed
Conditions:Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:June 2011
End Date:September 2015

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Trial Summary
Trial Overview
Inclusion Criteria

Archer 1009: A Randomized, Double Blind Phase 3 Efficacy And Safety Study Of PF-00299804 (Dacomitinib) Versus Erlotinib For The Treatment Of Advanced Non-Small Cell Lung Cancer Following Progression After, Or Intolerance To, At Least One Prior Chemotherapy

This is a multinational, multicenter, randomized,double-blinded, Phase 3 study comparing the
efficacy and safety of treatment with PF-00299804 to treatment with erlotinib in patients
with advanced non-small cell lung cancer, previously treated with at least one prior
regimen. Analyses of primary objective (Progression Free Survival) will be done in two
co-primary populations as defined in the protocol.


Inclusion Criteria:

- Evidence of pathologically confirmed, advanced NSCLC (with known histology).

- Prior treatment with at least one and no more than two systemic therapy regimens (at
least one must be standard chemotherapy for advanced NSCLC).

- Adequate tissue sample must be submitted prior to randomization for tumor biomarker
analyses.

- Adequate renal, hematologic, liver function.

- ECOG PS of 0-2.

- Radiologically measurable disease.

Exclusion Criteria:

- Small cell histology.

- Symptomatic brain mets or known leptomeningeal mets.

- Prior therapy with agent known or proposed to be active by action on EGFR tyrosine
kinase or other HER family proteins.

- Uncontrolled medical disorders.
We found this trial at
103
sites
John B. Amos Cancer Center
1831 Fifth Avenue
Columbus, Georgia 31904
(706) 320-8700
John B. Amos Cancer Center The John B. Amos Cancer Center located in Columbus, Georgia,...
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University of Alabama at Birmingham
1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
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Birmingham, AL
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Central Coast Medical Oncology Corporation
220 S Palisade Dr # 204
Santa Maria, California 93454
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Santa Maria, CA
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Seattle Cancer Care Alliance
825 Eastlake Ave E
Seattle, Washington 98109
(206) 288-7222
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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Seattle, WA
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Central Hematology/Oncology Medical Group, Inc.
Alhambra, California 91801
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Alhambra, CA
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UCLA Hematology/Oncology - Alhambra
Alhambra, California 91801
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Alhambra, CA
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Illinois Cancer Specialists
Arlington Heights, Illinois 60005
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Arlington Heights, IL
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The Emory Clinic
Atlanta, Georgia 30322
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Atlanta, GA
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Winship Cancer Institute at Emory University
1365 Clifton Rd NE
Atlanta, Georgia 30322
(404) 778-1900
Winship Cancer Institute at Emory University Winship Cancer Institute of Emory University is Georgia
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Emory University Hospital Midtown
550 Peachtree St NE
Atlanta, Georgia 30308
(404) 686-4411
Emory University Hospital Midtown Emory University Hospital Midtown is a 511-bed community-based, acute care teaching...
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Emory University Hospital
1364 Clifton Rd NE
Atlanta, Georgia 30322
(404) 712-2000
Emory University Hospital As the largest health care system in Georgia and the only health...
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Northwest Georgia Oncology Centers, P.C.
Austell, Georgia 30106
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Austell, GA
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Northwest Georgia Oncology Centers, P.C.
Carrollton, Georgia 30117
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Northwest Georgia Oncology Centers, P.C.
Cartersville, Georgia 30121
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Ironwood Cancer and Research Centers P. C.
Chandler, Arizona 85224
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Ironwood physicians P.C. dba Ironwood Cancer & Research Centers
Chandler, Arizona 85224
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Good Samaritan Hospital Samaritan Ambulatory Infusion Services
Corvallis, Oregon 97330
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Samaritan Hematology & Oncology Consultants
Corvallis, Oregon 97330
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Samaritan Pharmacy Services
Corvallis, Oregon 97330
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Siteman Cancer Center-West County
Creve Couer, Missouri 63141
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Atlanta Cancer Care
Decatur, Georgia 30033
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Decatur, GA
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Georgia Cancer Specialists
Decatur, Georgia 30033
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Decatur, GA
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The Cancer Center at DeKalb Medical
Decatur, Georgia 30033
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Decatur, GA
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Oncology Hematology Specialists, P.A.
Denville, New Jersey 07834
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Denville, NJ
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Karmanos Cancer Institute
Detroit, Michigan 48201
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Detroit, MI
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Northwest Georgia Oncology Centers, P.C.
Douglasville, Georgia 30134
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City of Hope
Duarte, California 91010
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Suburban Hematology-Oncology Associates, P.C.
Duluth, Georgia 30096
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Deaconess Clinic Downtown
Evansville, Indiana 47713
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Evansville, IN
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Karmanos Cancer Institute at Farmington Hills
Farmington Hills, Michigan 48334
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Highlands Oncology Group, P.A.
Fayetteville, Arkansas 72703
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Fayetteville, AR
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Northwest Alabama Cancer Center
Florence, Alabama 35630
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St. Jude Heritage Healthcare
Fullerton, California 92835
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Fullerton, CA
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Oncology Specialists of North Georgia, LLC
Gainesville, Georgia 30501
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Gainesville, GA
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The Longstreet Clinic Cancer Center
Gainesville, Georgia 30501
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Northeast Georgia Medical Center
743 Spring St NE
Gainesville, Georgia 30501
770-219-9000
Northeast Georgia Medical Center Northeast Georgia Health System (NGHS) is a not-for-profit community health system...
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Ironwood physicians P.C. dba Ironwood Cancer & Research Centers
Gilbert, Arizona 85297
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Gilbert, AZ
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Ingalls Memorial Hospital - In-Patient Pharmacy
Harvey, Illinois 60426
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Harvey, IL
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Ingalls Memorial Hospital
1 Ingalls Dr
Harvey, Illinois 60426
(708) 333-2300
Ingalls Memorial Hospital As the area's only independent not-for-profit healthcare system, Ingalls has the ability...
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Monroe Medical Associates
Harvey, Illinois 60426
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Kentucky Cancer Clinic
Hazard, Kentucky 41701
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Hazard, KY
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Carolina Oncology Specialists, PA
Hickory, North Carolina 28602
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Hickory, NC
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Kadlec Clinic Hematology and Oncology
Kennewick, Washington 99336
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Kennewick, WA
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Suburban Hematology/Oncology Associates, Pc
Lawrenceville, Georgia 30046
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Lawrenceville, GA
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Dartmouth-Hitchcock Medical Center /Mary Hitchcock Memorial Hospital
Lebanon, New Hampshire 03756
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Lebanon, NH
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Carolina Oncology Specialists PA
Lenoir, North Carolina 28645
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Lenoir, NC
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Samaritan North Lincoln Hospital
Lincoln City, Oregon 97367
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Lincoln City, OR
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Texas Oncology-Longview Cancer Center
Longview, Texas 75601
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Longview, TX
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Drug Management Only
Los Angeles, California 90095
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UCLA West Medical Pharmacy
Los Angeles, California 90095
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Administrative Address: UCLA Hematology Oncology-Clinical Research Unit (CRU)
Los Angeles, California 90095
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Drug Shipment Address: Ronald Reagan UCLA Medical Center, Drug Information Center
Los Angeles, California 90095
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Regulatory Management:
Los Angeles, California 90095
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Ronald Reagan UCLA Medical Center
Los Angeles, California 90095
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TORI Central Administration
Los Angeles, California 90095
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Westwood Bowyer Clinic, Peter Morton Medical Building
Los Angeles, California 90095
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University Medical Center, Inc
Louisville, Kentucky 40202
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Baptist Hospital East
Louisville, Kentucky 40207
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University of Louisville
500 S Preston St
Louisville, Kentucky
(502) 852-5555
University of Louisville The University of Louisville is a state supported research university located in...
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Northwest Georgia Oncology Centers, PC
Marietta, Georgia 30060
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Marietta, GA
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Desert Oncology Associates dba Ironwood Cancer and Research Centers
Mesa, Arizona 85202
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Mesa, AZ
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Ironwood physicians P.C. dba Ironwood Cancer & Research Centers
Mesa, Arizona 85206
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University of South Alabama Mitchell Cancer Institute
1660 Springhill Avenue
Mobile, Alabama 36604
(251) 665-8000
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University of South Alabama Medical Center
Mobile, Alabama 36604
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Monroe Medical Associates
Munster, Indiana 46321
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Northwest Alabama Cancer Center, PC
Muscle Shoals, Alabama 35661
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Samaritan Pacific Communities Hospital
Newport, Oregon 97365
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Newport, OR
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Illinois Cancer Specialists
Niles, Illinois 60714
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Niles, IL
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Norwalk Hospital
Norwalk, Connecticut 06856
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Norwalk, CT
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Mercy Physicians of Oklahoma-Communities, Inc. - Mercy Clinic Oncology/Hematology - McAuley
Oklahoma City, Oklahoma 73120
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Oklahoma City, OK
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Mercy Physicians of Oklahoma
Oklahoma City, Oklahoma 73112
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Florida Hospital
601 E Rollins St
Orlando, Florida 32803
(407) 303-5600
Florida Hospital Florida Hospital is one of the country
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Cancer Institute Of Florida
Orlando, Florida 32804
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Hematology and Oncology Consultants, PA
Orlando, Florida 32804
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Orlando, FL
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Investigational Drug Services, Florida Hospital
Orlando, Florida 32804
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UCLA/Pasadena HealthCare Hematology Oncology
Pasadena, California 91105
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Central Hematology Oncology Medical Group Inc.
Pasadena, California 91107
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Hematology Oncology Associates Of The Treasure Coast
Port St. Lucie, Florida 34952
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Port St. Lucie, FL
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Cancer Care Associates Medical Group, Inc.
Redondo Beach, California 90277
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Redondo Beach, CA
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Kadlec Medical Center
Richland, Washington 99352
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Richland, WA
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Outpatient Imaging Center
Richland, Washington 99352
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Richland, WA
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Highlands Oncology Group
Rogers, Arkansas 72758
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Rogers, AR
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Siteman Cancer Center-St. Peters
Saint Peters, Missouri 63376
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Saint Peters, MO
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UCLA Hematology Oncology-Parkside
Santa Monica, California 90404
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Santa Monica, CA
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UCLA Hematology-Oncology Santa Monica
Santa Monica, California 90404
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UCLA Santa Monica Medical Center & Orthopedic Hospital
Santa Monica, California 90404
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Guthrie Clinic Limited
Sayre, Pennsylvania 18840
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Sayre, PA
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Robert Packer Hospital
Sayre, Pennsylvania 18840
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University of Washington Medical Center
1959 NE Pacific St
Seattle, Washington 98195
(206) 598-3300
University of Washington Medical Center University of Washington Medical Center is one of the nation's...
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Suburban Hematology-Oncology Associates
Snellville, Georgia 30078
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Snellville, GA
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City of Hope- South Pasadena Cancer Center
South Pasadena, California 91030
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Washington University School of Medicine-IDS Pharmacy
St. Louis, Missouri 63110
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Barnes Jewish Hospital
1 Barnes Jewish Hospital Plaza
St. Louis, Missouri 63110
(314) 747-3000
Barnes Jewish Hospital Barnes-Jewish Hospital at Washington University Medical Center is the largest hospital in...
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North Mississippi Hematology and Oncology Associates, Ltd.
Starkville, Mississippi 39759
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Stony Brook University Cancer Center
3 Edmund D. Pellegrino Road
Stony Brook, New York 11794
(631) 638-1000
Stony Brook University Cancer Center Ask a cancer survivor. Having highly advanced care close to...
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Monroe Medical Associates
Tinley Park, Illinois 60477
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North Mississippi Hematology And Oncology Associates, Ltd
Tupelo, Mississippi 38801
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Tupelo, MS
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Texas Oncology-Tyler
Tyler, Texas 75702
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UCLA Santa Clarita Valley Cancer Center
Valencia, California 91355
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Sozialmedizinisches Zentrum Baumgartner Hoehe - Otto Wagner Spital und Pflegezentrum
Vienna,
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Texas Oncology-Waco
Waco, Texas 76712
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