Prospective Multicenter Trial to Explore the Tolerability and Safety of the H-Coil Deep TMS in Combination With Serotonin Selective Reuptake Inhibitor(SSRI)

Inclusion Criteria:

- Outpatients

- Men and women 22-68 years of age

- Primary DSM-IV diagnosis of Major Depression, single or recurrent episode confirmed by
the Structured Clinical Interview for the DSM-IV (SCID-IV).

- Completed the CTP-0001-00 study according to the protocol, i.e., either completed 16
weeks of treatment, or were discontinued from the CTP-0001-00 study protocol after 6
weeks or more from randomization.

- Capable and willing to provide informed consent.

- Able to adhere to the treatment schedule.

Exclusion Criteria:

- Discontinued from CTP-0001-00 study protocol due to the following reasons:
Tolerability and safety reason, Non-compliant with the study protocol, Developed
documented suicidal ideation as assessed by the investigator or significant suicide
risk based on HDRS-21 item 3 score of 3 or 4 or suicidal attempt

- Current psychotic disorder

- Sensitivity or allergic or other severe adverse event previously reported for
Citalopram, Escitalopram, Fluoxetine, Paroxetine, or Sertraline.

- Known or suspected pregnancy

- Women of childbearing potential and not using a medically accepted form of
contraception when engaging in sexual intercourse.

- Minimal MT found for both hands is higher than 75% of stimulator power output.