National Marrow Donor Program Long-Term Donor Follow-Up

This is an observational study of unstimulated bone marrow (BM) and filgrastim-mobilized
peripheral blood stem cell (PBSC) donors. The primary goal is to evaluate the hypothesis that
the incidence of targeted malignant, thrombotic and autoimmune disorders after unrelated
hematopoietic stem cell donation are similar between unstimulated BM and filgrastim-mobilized
PBSC donors. Donors will undergo biennial surveys until study completion. Cases of targeted
disorders will be reviewed by the medical monitors to confirm the veracity of the report.

Inclusion Criteria:

1. Unrelated donor who donated either unstimulated BM or filgrastim-mobilized PBSC
between July 1, 1999 and approximately five years post study activation.

2. Unrelated donor who received at least one injection of filgrastim or more, but did not
donate filgrastim-mobilized PBSC between July 1, 1999 and approximately five years
post study activation.

3. Donation was managed by a U.S. NMDP donor center.

4. Signed informed consent for participation in this long-term donor follow-up study.
Concurrent enrollment on other studies is permitted.

Exclusion Criteria:

1. Unrelated donor who donated filgrastim-mobilized bone marrow.

2. Donation was managed by a non-U.S. donor center.

3. Donor is unable to verbally communicate in any of the following languages: English,
Spanish, Mandarin Chinese, Cantonese Chinese, Vietnamese, Korean, or Portuguese.