Safety and Pharmacokinetics of Dapivirine/Maraviroc Vaginal Ring

Inclusion Criteria:

- Age 18 through 40 years (inclusive) at screening, verified per site SOPs

- Able and willing to provide written informed consent to be screened for and take part
in the study

- Able and willing to provide adequate locator information, as defined by the site SOPs

- HIV-uninfected, based on testing performed by study staff at Screening and Enrollment
(per applicable algorithm in Appendix II)

- In general good health at Screening and Enrollment, as determined by the site IoR or
designee

- At Screening, participant states willingness to abstain from receptive sexual
activity (including oral, vaginal and anal intercourse) for the 14 days prior to
enrollment and for the duration of study participation

- Per participant report, using an effective method of contraception at Enrollment, and
intending to continue use of an effective method for the duration of study
participation. Effective methods include hormonal methods (except contraceptive
vaginal rings), intrauterine device (IUD) inserted at least 28 days prior to
enrollment, being a woman who identifies as a woman who has sex with women
exclusively, sterilization, and/or sexually abstinent for the past 90 days

- Satisfactory Pap result in the 12 calendar months prior to Enrollment consistent with
Grade 0 according to the Female Genital Grading Table for Use in Microbicide Studies
Addendum 1 to the DAIDS Table for Grading Adult and Pediatric Adverse Events, Version
1.0, December 2004 (Clarification dated August 2009), or satisfactory evaluation with
no treatment required of Grade 1 or higher Pap result per American Society for
Colposcopy and Cervical Pathology (ASCCP) guidelines in the 12 calendar months prior
to Enrollment.

- Per participant report at Screening and Enrollment, agrees not to participate in
other research studies involving drugs, medical devices, or vaginal products for the
duration of study participation

- Per participant report at Screening, regular menstrual cycles with at least 21 days
between menses (does not apply to participants who report using a progestin-only
method of contraception at screening, e.g., Depo-Provera or levonorgestrel-releasing
IUD)

- At Screening and Enrollment, participant states a willingness to refrain from
inserting any non-study vaginal products or objects into the vagina, including but
not limited to, spermicides, female condoms, diaphragms, contraceptive vaginal rings,
vaginal medications, menstrual cups, cervical caps (or any other vaginal barrier
method), douches, lubricants, sex toys (vibrators, dildos, etc.), and tampons for the
5 days prior to enrollment throughout the duration of study participation. -- Note:
At the Screening visit participant also agrees to refrain from the practices listed
above for at least 5 days prior to enrollment.

Exclusion Criteria:

- Participant report of any of the following at Screening:

- Known adverse reaction to silicone, titanium dioxide, or to any of the
components of the study products

- Use and/or anticipated use during the period of study participation of CYP3A
inducer(s) and/or inhibitor(s)

- Chronic and/or recurrent candidiasis

- Non-therapeutic injection drug use in the 12 months prior to screening

- Post-exposure prophylaxis for HIV exposure within 6 months prior to screening

- Last pregnancy outcome 90 days or less prior to screening

- Currently breastfeeding

- Hysterectomy

- Intends to become pregnant within the next 4 months

- Has plans to relocate away from the study site area in the next 4 months

- Reports participating in any other research study involving drugs, medical devices,
or vaginal products 60 days or less prior to enrollment

- At Screening or Enrollment, as determined by the IoR/designee, any significant
uncontrolled active or chronic cardiovascular, renal, liver, hematologic, neurologic,
gastrointestinal, psychiatric, endocrine, respiratory, immunologic disorder or
infectious disease, or at increased risk of cardiovascular events

- Has any of the following laboratory abnormalities at Screening:

- Aspartate aminotransferase (AST) or alanine transaminase (ALT) Grade 1 or higher
as per the Division of AIDS Table for Grading the Severity of Adult and
Pediatric Adverse Events Version 1.0, December, 2004 (Clarification dated August
2009)

- Calculated creatinine clearance less than 60 mL/min by the Cockcroft- Gault
formula, where creatinine clearance (female) in mL/min = (140 - age in years) x
(weight in kg) x (0.85)/72 x (creatinine in mg/dL)

- Hemoglobin Grade 1 or higher as per the Division of AIDS Table for Grading the
Severity of Adult and Pediatric Adverse Events Version 1.0, December, 2004
(Clarification dated August 2009)

- Platelet count Grade 1 or higher as per the Division of AIDS Table for Grading
the Severity of Adult and Pediatric Adverse Events Version 1.0, December, 2004
(Clarification dated August 2009) --- Note: Otherwise eligible participants with
an exclusionary test result may be retested during the screening process. If a
participant is re- tested and a nonexclusionary result is documented within 45
days of providing informed consent for screening, the participant may be
enrolled.

- At Screening or Enrollment, is pregnant

- Diagnosed with urinary tract infection (UTI) at Screening or Enrollment

-- Note: Otherwise eligible participants diagnosed with UTI during screening will be
offered treatment and may be enrolled after completing treatment and all symptoms
have resolved. If treatment is completed and symptoms have resolved within 45 days of
obtaining informed consent for screening, the participant may be enrolled.

- Diagnosed with pelvic inflammatory disease, a sexually transmitted infection (STI) or
reproductive tract infection (RTI) requiring treatment per current Centers for
Disease Control and Prevention (CDC) guidelines (http://www.cdc.gov/std/treatment/)
at Screening or Enrollment

-- Note: Otherwise eligible participants diagnosed with STI or RTI during screening
will be offered treatment and may be enrolled after completing treatment and all
symptoms have resolved. If treatment is completed and symptoms have resolved within
45 days of obtaining informed consent for screening, the participant may be enrolled.

- At Screening or Enrollment, has a clinically apparent Grade 1 or higher pelvic exam
finding (observed by study clinician or designee) per the Division of AIDS Table for
Grading the Severity of Adult and Pediatric Adverse Events, Version 1.0, December
2004 (Clarification dated August 2009), Addendum 1, Female Genital Grading Table for
Use in Microbicide Studies

-- Note: Cervical friability bleeding associated with speculum insertion and/or
specimen collection judged to be within the range of normal according to the clinical
judgment of the IoR/designee is considered expected non-menstrual bleeding and is not
exclusionary.

- At Screening, severe pelvic relaxation such that either the vaginal walls or the
uterine cervix descend beyond the vaginal introitus with valsalva maneuver

- Has any other condition that, in the opinion of the IoR/designee, would preclude
informed consent, make study participation unsafe, complicate interpretation of study
outcome data, or otherwise interfere with achieving study objectives.