A Study To Assess Effects Of PF-04958242 On Bold Functional Magnetic Resonance Imaging During Working Memory Activation And Arterial Spin Labeling At Rest In Healthy Subjects
| Status: | Completed |
|---|---|
| Conditions: | Schizophrenia |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/18/2012 |
| Start Date: | June 2011 |
| End Date: | November 2012 |
| Contact: | Pfizer CT.gov Call Center |
| Phone: | 1-800-718-1021 |
Subject And Investigator-Blinded, Sponsor-Open, Randomized, Single-Dose, Placebo-Controlled, Parallel Group Study To Assess Effects Of PF-04958242 On Bold Functional MRI During Working Memory Activation And Arterial Spin Labeling At Rest In Healthy Subjects
This study aims to determine whether the drug affects brain activity in healthy volunteers,
either when the participants are performing a memory task, or when lying at rest. Subjects
will undergo a brain scan under both of these conditions after a dose of either the study
drug or a placebo is administered.
Inclusion Criteria:
- Healthy male and/or female subjects of non-childbearing potential between the ages of
21 and 55 years, inclusive
- Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight >50 kg (110 lbs)
Exclusion Criteria:
- History of seizures or of a condition with risk of seizures; head injury; any history
of DSM-IV Axis I psychiatric disorders; contraindications for MRI
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