Lexapro for the Treatment of Traumatic Brain Injury (TBI) Depression & Other Psychiatric Conditions
| Status: | Completed |
|---|---|
| Conditions: | Depression, Major Depression Disorder (MDD), Neurology, Psychiatric |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/2/2013 |
| Start Date: | April 2010 |
| End Date: | December 2012 |
| Contact: | Alyssa Bergey, M.A. |
| Email: | abergey1@jhmi.edu |
| Phone: | 410-550-9022 |
Escitalopram (Lexapro) for the Treatment of TBI Depression and Other Comorbid Psychiatric Conditions
This research is being done to see if a drug called escitalopram (Lexapro) is helpful to
people who are suffering from depression after traumatic brain injury (TBI).
Despite it's high prevalence, little is known about the pharmacological treatment of
depression following Traumatic Brain Injury (TBI). This is because of a lack of randomized
controlled studies in the treatment of post-TBI depression. This study is designed to
examine the safety and effectiveness of escitalopram in the treatment of post-TBI
depression. It will also investigate metabolic changes and neural pathways associated with
post-TBI depression and metabolic alterations after treatment through neuroimaging.
Inclusion Criteria:
- Closed head injury
- Fulfill DSM IV criteria "Major Depressive Disorder"
- 18 years of age or older
- Able to provide informed consent
- Stable medical history
Exclusion Criteria:
- History of Stroke, Encephalitis, Seizures, or any other pre-TBI neurological diseases
- History of mental retardation
- Alcohol or Substance dependence in the last 1 year
- Inability to undergo MRI scan
- Pregnancy
- Current use of any psychotropic medications including any antidepressants,
antipsychotics, anxiolytics, or sedative hypnotics
- Poor response to escitalopram in the past
- Acutely suicidal or requiring inpatient psychiatric hospitalization, as determined by
the study psychiatrist
- Good medication response to another antidepressant in the past
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Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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