A Study of LY2495655 in Older Participants Undergoing Elective Total Hip Replacement

Inclusion Criteria:

- Males with a female partner of childbearing potential should use contraception during
the treatment period of the trial and up to 15 weeks after the last dose of
investigational product.

- Females should be of non-child bearing potential.

- Elective total hip arthroplasty (eTHA) is scheduled.

- Have a body mass index of <40 kilograms per square meter (kg/m^2) and a weight <136.4
kilograms (kg).

- Can climb at least 6 stairs with or without holding the handrail (but without human
assistance), according to the participant at screening.

- Can stand up from a chair and walk more than 10 meters without human assistance.

- Takes at least 12 seconds to perform the Timed Up and Go (TUG) test at screening.

Exclusion Criteria:

- Another inpatient surgical procedure is planned in the 6 months following
randomization.

- Lower extremity amputation.

- Lower-limb fracture within 6 months prior to screening or any major lower-limb surgery
within 3 months prior to randomization.

- Simultaneous bilateral eTHA.

- The planned surgical procedure will preclude weight bearing for at least 4 weeks
postoperatively (for instance, the planned procedure will involve extensive bone
grafting). "Partial weight-bearing" and "weight-bearing as tolerated" are acceptable,
but "non weight-bearing," "touch weight-bearing," or "feather weight-bearing" are
exclusive.

- Underlying muscle disease (for example, polymyositis or muscular dystrophy) or a
history of muscle disease other than age-associated muscle waste or disuse atrophy.

- Recent neurologic injury (<6 months prior to randomization) such as stroke or spinal
cord injury, or unstable neurologic disorders that are likely to confound physical
performance tests during the course of the study (such as unstable Parkinson disease
or hemiplegia).

- History of positive testing for human immunodeficiency virus (HIV).

- Current use or previous use of any drugs known to influence muscle mass or performance
within 6 months prior to randomization (this includes anabolic steroids, replacement
therapy for gonadal deficiency, anti-androgens, luteinizing hormone-releasing hormone
[LHRH] agonist and antagonists, growth hormone, Insulin-Like Growth Factor 1 [IGF1],
or creatinine supplements) or systemic corticosteroid use for at least 3 months (in
the last year) prior to randomization at a daily dose greater than or equal to a 10 mg
prednisone equivalent.

- Severe Vitamin D deficiency defined as 25-hydroxy-vitamin D levels <9.2 nanograms per
milliliter (ng/mL) or <23 nanomoles per milliliter (nmol/mL) at screening.

- History of a malignant neoplasm in the 5 years prior to screening, with the exception
of superficial basal cell carcinoma or squamous cell carcinoma of the skin that has
been definitively treated. Participants with carcinoma in situ of the uterine cervix
treated definitively for more than 1 year prior to screening may enter the study.

- History of any of the following conditions within 90 days of screening: unstable
angina, myocardial infarction, coronary artery bypass graft surgery, or percutaneous
coronary intervention (such as, angioplasty or stent placement).

- Any current supraventricular arrhythmia with an uncontrolled ventricular response
(mean heart rate >100 beats per minute [bpm]) at rest despite medical or device
therapy, any history of spontaneous or induced sustained ventricular tachycardia
(heart rate >100 bpm for 30 seconds) despite medical or device therapy, or any history
of resuscitated cardiac arrest or the presence of an automatic internal
cardioverter-defibrillator.

- Any history of congestive heart failure within 6 months of screening.

- Systolic blood pressure >160 or <90 millimeters of mercury (mmHg) or diastolic blood
pressure >100 or <50 mmHg at screening, or malignant hypertension.

- An abnormality in the locally read 12-lead electrocardiogram (ECG) that in the opinion
of the investigator increases the risk of participating in the study.

- Have either or both of the following: aspartate aminotransferase (AST), alanine
aminotransferase (ALT) >2 times the upper limit of normal (ULN), or alkaline
phosphatase >1.5 times ULN, or total bilirubin >1.5 times ULN.

- Known history or presence of severe acute or chronic liver disease.

- History of significant renal insufficiency, defined as receiving renal dialysis or
having an estimated creatinine clearance <30 milliliters per minute (mL/minute) at
screening.

- Current evidence or recent history of significant psychiatric disease such as
dementia/Alzheimer's disease, schizophrenia, or bipolar disorder.

- Are currently enrolled in, or discontinued within the last 30 days (or 5 half-lives
whichever is longer) from a clinical trial involving an investigational drug or
off-label use of a drug, or are concurrently enrolled in any other type of medical
research judged not to be scientifically or medically compatible with this study.

- Regularly uses known drugs of abuse and/or shows positive findings on urinary drug
screening (physician prescribed narcotics are allowed).

- Have a positive fecal occult blood (FOB) test at screening or cannot provide a stool
sample for FOB testing prior to randomization.

- Have uncontrolled diabetes mellitus.

- Have had ocular trauma, ophthalmologic surgery, or eye laser treatment within 6 months
prior to randomization.