A Relative Efficacy and Safety Study of OC Oral Solution for Sialorrhoea in Patients With Parkinson's Disease

Sialorrhea is excessive flow of saliva associated with its unintentional loss from the mouth,
commonly known as drooling. Sialorrhea may result from any combination of hypersecretion,
problems swallowing or sensorimotor problems containing saliva in the mouth. It is commonly
found in people with neurological dysfunction such as Parkinson's Disease, leading to social
isolation and embarrassment. In general, treatment options are limited because of the
underlying chronic disease. The objective of the proposed low-dose, new combination drug, OC
Oral solution is to develop a new treatment option that can be used to titrate saliva
secretion rates to a level that is low enough to prevent unintentional loss (i.e. drooling)
but not so low as to cause an uncomfortably dry mouth.

Inclusion Criteria:

- Diagnosis of Parkinson's Disease for at least 2 years

- Patients with a score of ≥2 on the salivation section of UPDRS, item 6

- Patients Hoehn and Yahr stage must be ≤4

- under stable anti-Parkinson therapy throughout the study

- Able and willing to comply with the study procedures

- Able to provide and provision of a written informed consent

Exclusion Criteria:

- Female who is pregnant/lactating or planning to be pregnant

- Must not have a form of drug-induced or atypical parkinsonism or parkinsonism with
swallow problems due to other etiology

- Have current uncontrolled hypertension, symptomatic postural hypotension, active
Raynaud's disease or other peripheral vascular occlusive disease

- Have a history or presence of hyperthyroidism, congestive heart failure, coronary
heart disease, cardiac arrhythmias, tachycardia or severe bradycardia resulting from
either sick sinus syndrome or AV block of 2nd or 3rd degree

- Have a history of narrow angle glaucoma or shallow anterior chamber

- Have a history or presence of gastrointestinal obstruction, including paralytic ileus
and intestinal atony or gastrointestinal motility disorders, toxic megacolon or severe
ulcerative colitis

- Have a history or presence of bladder outflow obstruction or urinary retention

- Patients with hepatic or renal impairment

- Male with QTc > 430 ms or female with QTc > 450 ms ECG results at screening

- Concomitant use of α2-agonist, anticholinergic medication or other medications that
affect ACh levels

- Have a history of alcohol or substance abuse

- Any condition, including the presence of laboratory abnormalities, which places the
patient at unacceptable risk to participate in the study or confounds the ability to
interpret data from the study

- Have a history of hypersensitivity to the investigational medicinal product or any of
the excipients or to medicinal products with similar chemical structures

- Have received treatment with any other investigational medicinal product in the last 6
weeks before administration of the first dose in this clinical study

- Have received treatment with any medicinal product known to have a well-defined
potential for toxicity to a major organ in the previous 3 months

- Have a positive result of the human immunodeficiency virus (HIV) 1 and 2 test

- Have problems to understand the protocol requirements, instructions and study related
restrictions, the nature, scope and possible consequences of the clinical study

- Are unlikely to comply with the protocol requirements, instructions and study related
restrictions

- Patient is the Investigator or any sub-investigator, research assistant, pharmacist,
study coordinator, other staff or relative thereof directly involved in the conduct of
the clinical study

- Vulnerable subjects

- Have any concurrent disease or condition that, in the opinion of the Investigator,
would make the patient unsuitable for participation in the clinical study

- Donation of 500 ml or more of blood within the last 8 weeks before start of the study
and for at least 4 weeks after study completion

- Have previously been enrolled in this clinical study

- Vulnerable subjects