Does Hydroxyzine Decrease Anxiety in Underweight Patients Diagnosed With an Eating Disorder
| Status: | Withdrawn |
|---|---|
| Conditions: | Anxiety, Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 8 - 25 |
| Updated: | 4/21/2016 |
| Start Date: | January 2012 |
| End Date: | April 2013 |
Hydroxyzine Effects on Meal-Related Anxiety in Underweight Adolescents and Young Adults Diagnosed With an Eating Disorder - A Pilot Study
The purpose of this study is to determine the effectiveness of hydroxyzine in the treatment
of meal-related anxiety in adolescents and young adults 8 to 25 years of age diagnosed with
an eating disorder who are underweight. The investigators want to find out if hydroxyzine
given before meals will improve meal-related anxiety compared to no hydroxyzine.
of meal-related anxiety in adolescents and young adults 8 to 25 years of age diagnosed with
an eating disorder who are underweight. The investigators want to find out if hydroxyzine
given before meals will improve meal-related anxiety compared to no hydroxyzine.
This study is a practiced-based pilot study in follow-up to clinical observations made by
our treatment team that hydroxyzine attenuates meal-related anxiety and improves treatment
adherence in patients with a diagnosis of Anorexia Nervosa (AN) (excluding the amenorrhea
criterion) or Eating Disorder Not Otherwise Specified (EDNOS) specifically with low BMI (≤
18). To our knowledge, hydroxyzine has never been formally investigated in treating
meal-related anxiety and improving outcomes in patients with AN or EDNOS specifically with
low BMI (≤ 18).
our treatment team that hydroxyzine attenuates meal-related anxiety and improves treatment
adherence in patients with a diagnosis of Anorexia Nervosa (AN) (excluding the amenorrhea
criterion) or Eating Disorder Not Otherwise Specified (EDNOS) specifically with low BMI (≤
18). To our knowledge, hydroxyzine has never been formally investigated in treating
meal-related anxiety and improving outcomes in patients with AN or EDNOS specifically with
low BMI (≤ 18).
Inclusion Criteria:
- Admitted to the Intensive Structured Living Unit (ISL) at Melrose Institute for
treatment of an eating disorder that meets DSM-IV criteria for Anorexia Nervosa
(excluding the amenorrhea criterion), or Eating Disorder Not Otherwise Specified,
specifically with BMI (≤ 18)
- Age 8-25 years old at admission to ISL.
- Weight ≥ 15 kg at admission to ISL.
- Stable psychotropic and/or sedative medications for at least (≥) 6 weeks
Exclusion Criteria:
- Age < 8 years
- Age ≥ 25 years
- Weight < 15 kg at admission to ISL
- Prolonged QT interval on ECG at admission to ISL
- Current substance or alcohol abuse or dependence
- Malabsorption syndrome or inability to take oral medications
- History of hydroxyzine intolerance or hypersensitivity
- History of Type 1 Diabetes Mellitus
- History of angle closure glaucoma
- Currently on another clinical trial
- Pregnancy
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