Role of Dopamine Receptors in Primary Focal Dystonias
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies, Neurology, Orthopedic |
| Therapuetic Areas: | Neurology, Orthopedics / Podiatry, Other |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 5/17/2018 |
| Start Date: | September 2011 |
| End Date: | April 2016 |
Dystonia is a disabling movement disorder characterized by repetitive patterned or sustained
muscle contractions causing twisting or abnormal postures that may afflict 250,000 people in
the U.S. While the pathophysiology of dystonia remains uncertain the treatment is rather
rudimentary. A better understanding of neural mechanisms of dystonias is not only an
invaluable prerequisite for developing better treatment options but also a step toward better
understanding of the complex network of basal ganglia. In this study I will investigate if
there is any difference between the dopamine receptors and dopamine in people with dystonia
and healthy subjects.
muscle contractions causing twisting or abnormal postures that may afflict 250,000 people in
the U.S. While the pathophysiology of dystonia remains uncertain the treatment is rather
rudimentary. A better understanding of neural mechanisms of dystonias is not only an
invaluable prerequisite for developing better treatment options but also a step toward better
understanding of the complex network of basal ganglia. In this study I will investigate if
there is any difference between the dopamine receptors and dopamine in people with dystonia
and healthy subjects.
Inclusion Criteria:
- Age >20
- Male or Female
- Any race or ethnicity
- Primary focal dystonia (arm or cranial)
- Ability to give informed consent
Exclusion criteria:
- Family history of dystonia
- Pregnancy (confirmed with negative urine pregnancy test in women of child bearing
potential), breastfeeding
- Exposure to radiation therapy
- Any MRI contraindications such as foreign metallic implants, pacemaker, and aneurysm
clip etc.
- History of cardiac disease, uncontrolled hypertension, abnormal EKG during screening
phase
- History of exposure to any drugs affecting dopaminergic systems within the last 6
months (e.g. dopamine receptor blocking agents, cocaine, amphetamine, tetrabenazine,
reserpine, L-dopa, dopamine agonists, as they might affect the dopamine receptor
binding or endogenous dopamine).
- Active depression (Beck Depression Inventory_II >14)
- Cognitive impairment (Mini-Mental State Score <27)
- CNS active medications such as gabapentin or narcotics, muscle relaxants which might
be given for pain in the 3 days prior to study
- History of stroke, seizure, cerebral palsy, generalized dystonia, parkinsonism,
inability to hold head still during the scanning time.
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