Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry

Collection of data to evaluate safety and characterize progression of Paroxysmal Nocturnal
Hemoglobinuria (PNH).

Inclusion Criteria:

- Patients of any age, including minors, with a diagnosis of PNH or a detected PNH
clone, including patients previously treated with Soliris and withdrawn from
treatment. Patients who are minors must have parent/legal guardian consent and must be
willing and able to give assent, if applicable as determined by the Ethics
Committees/Institutional Review Boards. Upon attaining adulthood, these patients must
be re-consented.

- Ability to comprehend and sign consent to have data entered in the PNH Registry.

Exclusion Criteria:

- Inability or unwillingness to sign informed consent.

- Patients currently enrolled in an interventional clinical trial for treatment of PNH
cannot be enrolled in the Registry at the same time.