Rheumatoid Arthritis Treatment and Biopsy Study Assessing Certolizumab Pegol (Cimzia)

Inclusion Criteria:

- Signed and dated informed consent document

- Subjects must be at least 18 years of age or older

- Subject must be willing and able to comply with scheduled visits, arthroscopy,
laboratory tests, and other procedures

- Diagnosis of RA based on ACR 1987 Revised Criteria

- Active disease at screening visit

- Methotrexate taken continuously for at least 12 weeks at a stable dosage

- Sexually active women of child-bearing potential and men whose partners are women of
child-bearing potential are required to use adequate contraceptive methods during
participation on this trial

- Treatment with non-steroidal anti-inflammatory drugs (NSAIDS)and oral corticosteroids
(less than or equal to 10 mg/day prednisone or equivalent)is accepted

Exclusion Criteria:

- Diagnosis of any other inflammatory arthritis

- History of infected joint prosthesis that is still in situ

- History of allergy to local anesthetic agents

- Pregnant or lactating women

- Current or recent history of uncontrolled clinically significant
conditions(e.g..,kidney disease, liver disease, class III or IV congestive heart
failure, according to the New York Heart Association)

- History or suspected demyelinating disease of the central nervous system, e.g.
multiple sclerosis or optic neuritis

- Current participation in clinical trial