Assess the Effect of Treating Periodontal Disease on Cardiovascular Function in Young Adults
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology, Dental |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Dental / Maxillofacial Surgery |
| Healthy: | No |
| Age Range: | 21 - 40 |
| Updated: | 3/30/2013 |
| Start Date: | December 2010 |
| End Date: | January 2013 |
| Contact: | Caroline Lambert, DDS |
| Phone: | 760.749.1410 |
Oral Flora, Periodontitis, and Vascular Dysfunction in Young Native Americans.
We propose to examine a population of Native Americans who have had little or no dental
care, and to determine if periodontal disease is associated with early signs of vascular
dysfunction or systemic inflammation. We then propose to treat the periodontitis and
re-evaluate vascular function. We will determine if gingivitis or mild/moderate
periodontitis is associated with detectable vascular dysfunction. Microbial metagenomics
will be correlated with vascular function.
Inclusion Criteria:
- American Indian/Alaskan Natives seeking health care at the Indian Health Council,
Inc.
- Males and females aged 21-40 years.
Exclusion criteria:
- Recent (within 6 months) periodontal treatment
- History of high blood pressure or existing heart disease
- Xerostomia
- Currently receiving treatment for cancer
- Currently taking anti-inflammatory medications (except H2 blockers, statins, or
medications that can affect periodontal status
- Immunosuppressed due to medication or HIV infection, or presence of active infection
such as hepatitis or tuberculosis
- Fewer than 20 teeth in functional dentition, excluding third molars, or other gross
oral pathology
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