OASIS: Osteoarthritis Sensitivity Integration Study
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Chronic Pain, Chronic Pain, Osteoarthritis (OA) |
| Therapuetic Areas: | Musculoskeletal, Rheumatology |
| Healthy: | No |
| Age Range: | 50 - Any |
| Updated: | 7/11/2015 |
| Start Date: | September 2011 |
| End Date: | June 2015 |
| Contact: | Kathy Scott, RN |
| Phone: | 734-615-6910 |
Central Pain Mechanisms in Osteoarthritis: A Randomized, Double-blind, Crossover Study to Evaluate the Effectiveness of Topical Diclofenac Versus Duloxetine for Chronic Osteoarthritis Pain
The primary objective of this study is to evaluate the relative efficacy of a
centrally-acting analgesic (duloxetine) versus a peripherally acting analgesic (topical
diclofenac) for pain and associated symptom management in knee osteoarthritis. Secondary
objectives include the determination of which self-report and experimental pain measures
best differentiate those who respond better to duloxetine than diclofenac.
centrally-acting analgesic (duloxetine) versus a peripherally acting analgesic (topical
diclofenac) for pain and associated symptom management in knee osteoarthritis. Secondary
objectives include the determination of which self-report and experimental pain measures
best differentiate those who respond better to duloxetine than diclofenac.
This is a randomized, blinded, crossover, controlled study design comparing duloxetine and
topical diclofenac for osteoarthritis pain.
The study cohort will be individuals who have a confirmed diagnosis of knee osteoarthritis.
Subjects will be randomized only after all entry criteria have been met. These individuals
will be evaluated at baseline, and then followed longitudinally following enrollment.
topical diclofenac for osteoarthritis pain.
The study cohort will be individuals who have a confirmed diagnosis of knee osteoarthritis.
Subjects will be randomized only after all entry criteria have been met. These individuals
will be evaluated at baseline, and then followed longitudinally following enrollment.
Inclusion Criteria:
- Diagnosed with knee osteoarthritis as defined by American College of Rheumatology
(ACR) criteria
- Males and females age greater than 50 years at time of screening
Exclusion Criteria:
- History of chronic kidney disease or moderate to severe hepatic impairment
- History of anemia
- Allergy or intolerance of drug intervention
- Inability to participate in outcome measures
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University of Michigan The University of Michigan was founded in 1817 as one of the...
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