Home-based Exercise for Management of HIV-associated Cardiovascular Disease Risk
| Status: | Completed |
|---|---|
| Conditions: | High Cholesterol, Obesity Weight Loss, Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Endocrinology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 11/30/2013 |
| Start Date: | March 2011 |
| End Date: | July 2013 |
| Contact: | Gregory A Hand, PhD |
| Email: | ghand@sc.edu |
| Phone: | 803-777-3908 |
Home-based Exercise for Management of HIV-associated Cardiovascular Disease
Because of advances in drug treatment, people living with HIV/AIDS (PLWHA) are living
longer, but are also at greater risk for cardiovascular disease (CVD) and diabetes.
Exercise and increased physical activity can reduce the risk factors for these diseases in
PLWHA, but no studies have tested an at-home exercise program that would benefit low income
people and others who do not have access to exercise facilities. This study will test the
feasibility of an at-home exercise program for PLWHA and prepare for a full-scale
intervention study, which may lead to a reduction in CVD risk among PLWHA.
Inclusion Criteria:
- Age 18 years and older
- Medical diagnosis of HIV-1 positive serostatus
- Sedentary lifestyle: not actively exercising ≥ 3 d•wk-1 for 20 min per session
- 18.5 kg/m2 < BMI < 40.0 kg/m2
- Stable, DHHS-approved ART regimen for previous 3 months, with HIV viral load below 75
copies/mL
- Capable of performing the required exercise regimen
- Have daily access to a telephone for approximately 10 months
- Capacity and willingness to provide informed consent and accept randomized group
assignment
Exclusion Criteria:
- Individuals who have a clinical history strongly suggestive of Type 1 diabetes.
- History of serious arrythmias, cardiomyopathy, congestive heart failure, stroke or
transient ischemic cerebral attacks, peripheral vascular disease with intermittent
claudication, myocardial infarction, or CABG.
- Malignancies in the past 5 years, except therapeutically controlled skin cancer.
- Plans to be away > 4 weeks in the next 9 months
- Score of 5 or greater on the DAST or MAST (signifying excessive use of drugs or
alcohol).
- Weight loss in excess of 10% body weight in previous 12 weeks.
- Chronic or recurrent respiratory, gastrointestinal, neuromuscular, neurological, or
psychiatric conditions.
- Inflammatory-related conditions such as collagen disorders.
- Any other medical condition or disease that is life-threatening or that can interfere
with or be aggravated by exercise.
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