Contrast Ultrasound Perfusion Imaging in Peripheral Arterial Disease (PAD)
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 19 - Any |
| Updated: | 4/21/2016 |
| Start Date: | July 2011 |
| End Date: | March 2016 |
| Contact: | Jonathan R Lindner, MD |
| Email: | lindnerj@ohsu.edu |
| Phone: | 5034948750 |
Contrast Ultrasound Perfusion Imaging in Peripheral Arterial Disease
Contrast ultrasound is a technique that can quantify blood flow in the tissues of the body
by ultrasound detection of microbubble contrast agents that behave in the circulation
similar to red blood cells. In this study, the investigators hypothesize that contrast
ultrasound of blood flow in the leg (thigh and calf) at rest and during stress produced by
medications that mimic exercise (vasodilator stress) can provide information on the location
and severity of peripheral vascular disease (blockages of the blood vessels in the leg). The
investigators will also determine whether symptom improvement after revascularization
(procedures to open up or bypass the blockages) is directly related to the improvement in
blood flow.
by ultrasound detection of microbubble contrast agents that behave in the circulation
similar to red blood cells. In this study, the investigators hypothesize that contrast
ultrasound of blood flow in the leg (thigh and calf) at rest and during stress produced by
medications that mimic exercise (vasodilator stress) can provide information on the location
and severity of peripheral vascular disease (blockages of the blood vessels in the leg). The
investigators will also determine whether symptom improvement after revascularization
(procedures to open up or bypass the blockages) is directly related to the improvement in
blood flow.
Inclusion Criteria:
1. Known or suspected PAD
2. Lower extremity angiography or MRA planned or performed within 6 months
Exclusion Criteria:
1. Age <19 y.o.
2. Pregnant or lactating females
3. Hypersensitivity to ultrasound contrast agent, dipyridamole, or regadenoson
4. Severe reactive airways disease
5. Evidence right-to-left shunt (identified on screening echo)
6. NYHA Class III or IV heart failure.
7. Planned amputation
8. Unstable coronary artery disease or severe aortic stenosis
We found this trial at
1
site
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Phone: 503-494-8750
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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