Head Circumference Growth in Children Who Develop Multiple Sclerosis Later in Life

Multiple sclerosis patients commonly develop generalized ventricular dilation with or
without cerebral atrophy over time. Case studies in the literature have noted some multiple
sclerosis patients develop the typical "normal pressure hydrocephalus" triad of dementia,
gait disturbance and incontinence which were responsive to shunts.

Many patients with connective tissue disorders (Ehlers-Danlos Syndrome) develop Multiple
Sclerosis and studies indicate that in the Multiple Sclerosis population, there exists over
10% more Ehlers-Danlos patients than in the normal population.

Because studies are indicating a form of external communicating hydrocephalus in the
Ehlers-Danlos population, the author hypothesizes the same type of hydrocephalus may occur
in the Multiple Sclerosis population.

To evaluate this hypothesis, investigators will retroactively evaluate the head
circumference of Multiple Sclerosis patients between birth and 15 months (before the skull
sutures have closed).

High pressure on the brain (even if subtle) could be evidence of congenital CCSVI
(cerebrospinal venous insufficiency), increased cerebrospinal fluid (CSF) production, the
poor drainage of cerebral spinal fluid, or a combination of all. Retrospective examination
of skull expansion is a necessary step to ascertain these possibilities, allowing for early
treatment and the hope of avoidance of the neurological symptoms, and often disabling
effects. It is the author's belief that "Benign External Hydrocephalus" is not a benign
condition.

Inclusion Criteria:

- Diagnosis of Multiple Sclerosis

Exclusion Criteria:

- Excludes CIS (clinically isolated syndrome)