Molecular Genetic and Pathological Studies of Anal Tumors

To determine the status of previously identified anal cancer molecular markers and any
correlations with outcome as well as to discover new molecular biomarkers through correlating
molecular data with clinical outcome. Study of tissue samples and cells from biopsies of your
lesion and blood sample. We hope to learn the role genes and proteins may play in the
development of anal cancer. Experiments will be performed using this tissue and blood,
include analysis of DNA, analysis of RNA expression levels, analysis of protein levels of
important gene products, and development of tissue culture cell lines.

Inclusion Criteria:Inclusion Criteria:

- Patients with anal tumors

- Undergoing surgery for elective colon and rectal surgery

Exclusion Criteria:No other patients other than adult patients with anal cancer or high
risk for anal cancer refered to Stanford will be enrolled to the study. No Children will be
included to the study