Biodistribution and Safety of the PET Probes [18F]FPRGD2 and [18F]FPPRGD2

Inclusion Criteria:

Healthy volunteers:

1. Must be 18 years of age or older.

2. Must have no known medical problems and have had a full medical exam within 6 months
of the study.

3. Must understand and voluntarily have signed an Informed Consent after its contents
have been fully explained.

4. Women of child bearing potential (as defined as women who are not post menopausal for
12 months or who have had no previous surgical sterilization) and men must agree to
use adequate contraception (hormonal or barrier method of birth control; abstinence)
prior to study entry, for the duration of study participation and for 30 days after
the last dose.

Cancer subjects:

1. Greater than 18 years-old at the time of radiotracer administration

2. Provides written informed consent

3. Diagnosed with advanced NSCLC, breast cancer, pancreatic cancer and GBM; patients will
undergo bevacizumab or Cyberknife therapy

4. Able to remain still for duration of each imaging procedure (about one hour)

Exclusion Criteria

1. Less than 18 years-old at the time of radiotracer administration

2. Pregnant or nursing