Sorafenib Tosylate, Bevacizumab, Irinotecan Hydrochloride, Leucovorin Calcium, and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer

PRIMARY OBJECTIVES:

I. To determine the maximally tolerated dose of the combination of irinotecan hydrochloride,
leucovorin calcium, and fluorouracil (FOLFIRI) plus sorafenib (sorafenib tosylate) plus
bevacizumab.

SECONDARY OBJECTIVES:

I. To assess the safety of FOLFIRI plus sorafenib plus bevacizumab. II. To assess the
feasibility of the proposed combination. III. To evaluate the response rate and identify any
activity of the proposed combination.

OUTLINE: This is a dose-escalation study of sorafenib tosylate followed by a cohort study.
(Cohort study cancelled as of March 25, 2014)

Patients receive irinotecan hydrochloride intravenously (IV) over 90 minutes on day 1,
leucovorin calcium IV over 2 hours on day 1, fluorouracil IV continuously over 46 hours on
days 1-2, bevacizumab IV over 30-90 minutes on day 1, and sorafenib tosylate orally (PO)
once (QD) or twice daily (BID) on days 3-6 and 10-13*. Courses repeat every 14 days in the
absence of disease progression or unacceptable toxicity.

NOTE: *Patients may also receive sorafenib tosylate on days 7 and 14.

After completion of study therapy, patients are followed up for 3 months.

Inclusion Criteria:

- This trial is intended for gastrointestinal malignancies appropriate for
irinotecan-based therapy; histologic proof of cancer that is now unresectable; if
prior therapy was received, patients must have shown progressive disease during prior
treatment or within 6 months of their most recent therapy

- Measurable disease or non-measurable disease

- Absolute neutrophil count (ANC) >= 1500/uL

- Platelet (PLT) >= 100,000/uL

- Hemoglobin (Hgb) >= 9.0 gm/dL

- Total bilirubin =< upper limit of normal (ULN)

- Alkaline phosphatase =< 3 x ULN

- Aspartate aminotransferase (AST) =< 3 x ULN OR AST =< 5 x ULN if liver involvement

- International normalized ratio (INR) < 1.5 unless patients are receiving
anti-coagulation therapy; patients receiving anti-coagulation therapy with an agent
such as warfarin or heparin are allowed to participate if INR =< 3.0

- Urine protein creatinine (UPC) ratio < 1 or urine dipstick < 2+

- NOTE: urine protein must be screened by urine analysis for UPC ratio or by
dipstick; for UPC ratio >= 1.0, 24-hour urine protein must be obtained and the
level should be < 1000 mg

- Creatinine =< 1.5 x ULN

- Calculated creatinine clearance must be >= 45 mL/min using the Cockcroft-Gault
formula

- Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 or 1

- Ability to provide informed consent

- Willing to return to Mayo Clinic for follow up

- Life expectancy >= 84 days (3 months)

- Women of childbearing potential only: negative pregnancy test done =< 7 days prior to
registration

Exclusion Criteria:

- Known standard therapy for patient's disease that is potentially curative

Note:

- Prior treatment with irinotecan, 5-fluoruracil or bevacizumab is allowed

- Prior treatment with sorafenib is not allowed

- Inadequately controlled hypertension (systolic blood pressure of > 150 mmHg or
diastolic pressure > 100 mmHg on anti-hypertensive medications)

- Prior history of hypertensive crisis or hypertensive encephalopathy

- History of myocardial infarction or unstable angina =< 6 months prior to
registration or congestive heart failure requiring use of ongoing maintenance
therapy for life-threatening ventricular arrhythmias

- Heart failure New York Heart Association classification III or IV

- Thrombolic or embolic events such as a cerebrovascular accident including
transient ischemic attacks =< 6 months prior to registration

- Any hemorrhage/bleeding event > grade 3 =< 4 weeks prior to registration

- Evidence or history of bleeding diathesis (greater than normal risk of bleeding)
or coagulopathy (in the absence of therapeutic anticoagulation); NOTE: patients
on full-dose anticoagulants are eligible provided the patient has been on a
stable dose for at least 2 weeks of low molecular weight heparin or warfarin and
has an INR in the range of 2-3; aspirin doses > 325 mg PO daily are not allowed

- Active or recent hemoptysis (>= ½ teaspoon of bright red blood per episode) =<
30 days prior to registration

- Serious, non-healing wound, active ulcer, or untreated bone fracture; NOTE:
patients with fractures secondary to metastatic disease are eligible after
appropriate radiotherapy

- Significant vascular disease (e.g., aortic aneurysm, aortic dissection), recent
peripheral arterial thrombosis, symptomatic peripheral vascular disease =< 6
months prior to registration

- History of abdominal fistula, gastrointestinal perforation, or intra-abdominal
abscess =< 6 months prior to registration

- Major surgical procedures, open biopsy, or significant traumatic injury =< 28
days prior to registration or anticipation of need for major surgical procedure
during the course of the study; EXCEPTION: core biopsy or minor surgical
procedure, including placement of a vascular access device, =< 7 days prior to
registration is allowed

- Patients taking cytochrome P450 enzyme-inducing antiepileptic drugs =< 4 weeks
prior to registration will be excluded (phenytoin, carbamazepine, phenobarbital,
rifampin, or St. John's wort)

- Known or suspected allergy or hypersensitivity to any agent given in the course
of this trial

- Any condition that impairs patient's ability to swallow whole pills

- Any malabsorption problem

- Any of the following prior therapies:

- Chemotherapy =< 14 days prior to registration

- Immunotherapy =< 28 days prior to registration

- Radiation therapy =< 28 days prior to registration

- Radiation to > 25% of bone marrow

- Failure to fully recover from acute, reversible effects of prior chemotherapy
regardless of interval since last treatment

- Known brain metastasis; NOTE: patients with neurological symptoms must undergo a
computed tomography (CT) scan/magnetic resonance imaging (MRI) of the brain to
exclude brain metastasis

- Any of the following:

- Pregnant women

- Nursing women

- Men or women of childbearing potential who are unwilling to employ adequate
contraception

- Other concurrent chemotherapy, immunotherapy, radiotherapy, or any ancillary
therapy considered investigational (utilized for a non-Food and Drug
Administration [FDA]-approved indication and in the context of a research
investigation)

- Receiving any other investigational agent which would be considered as a
treatment for the primary neoplasm

- Co-morbid systemic illnesses or other severe concurrent disease which, in the
judgment of the investigator, would make the patient inappropriate for entry
into this study or interfere significantly with the proper assessment of safety
and toxicity of the prescribed regimens

- Other active malignancy =< 3 years prior to registration; EXCEPTIONS:
non-melanotic skin cancer or carcinoma-in-situ of the cervix; NOTE: if there is
a history of prior malignancy, they must not be receiving other specific
treatment for their cancer, including hormonal therapy