Clinical Risk State for Bipolar Disorder in Adolescents
| Status: | Recruiting |
|---|---|
| Conditions: | Schizophrenia, Psychiatric, Bipolar Disorder |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 12 - 18 |
| Updated: | 2/22/2019 |
| Start Date: | September 2009 |
| End Date: | May 2020 |
| Contact: | Christoph U Correll, MD |
| Email: | ccorrell@lij.edu |
| Phone: | 7184704812 |
Characterizing the Clinical Risk State for Bipolar Disorder in Adolescents
Aim: The purpose of the study is to characterize the at-risk phases preceding a first episode
of bipolar disorder and of schizophrenia, and to identify clinical and biological predictors
of the disease development.
Hypothesis a: Over 6-24 months, 25% of at-risk youth will develop the full manifestations of
Bipolar Disorder (BPD) or schizophrenia.
Hypothesis b: The symptoms utilized for characterizing the at-risk phase of BPD will
differentiate between individuals developing BPD and schizophrenia.
of bipolar disorder and of schizophrenia, and to identify clinical and biological predictors
of the disease development.
Hypothesis a: Over 6-24 months, 25% of at-risk youth will develop the full manifestations of
Bipolar Disorder (BPD) or schizophrenia.
Hypothesis b: The symptoms utilized for characterizing the at-risk phase of BPD will
differentiate between individuals developing BPD and schizophrenia.
Prospective, naturalistic, cohort study aiming to characterizing the bipolar and psychotic
prodrome thoroughly with a variety of clinical and biological measures.
prodrome thoroughly with a variety of clinical and biological measures.
Inclusion Criteria:
1. Age: 12-18 years;
2. Sex: male or female;
3. Race/ethnicity: no restrictions;
4. Definite or suspected chart diagnosis of BP-II, BP-NOS, cyclothymia, MDD, depressive
disorder NOS, dysthymia or mood disorder NOS, schizophrenifiorm disorder or psychotic
disorder NOS;
5. Subject and parent (if subject<18) willing and able to provide written, informed
consent/assent.
Exclusion Criteria:
1. Estimated Premorbid IQ < 70;
2. Meets DSM-IV criteria for BP-I or schizophrenia, pervasive developmental disorder,
autism spectrum disorders, current substance dependence;
3. History of medical condition known to affect the brain;
4. current group home affiliation.
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