Evaluation of a Low-Cost High Resolution Microendoscope for the Detection of Lower Gastrointestinal Neoplasia

The overall objective of this study is to obtain data to evaluate whether high-resolution
imaging of the colon can assist clinicians in detecting dysplastic (precancerous) and
neoplastic areas. This is a pilot study of a novel technology, a miniaturized microscope
device which can be used during standard endoscopy to image the gastrointestinal epithelium.
Theoretically, by visualizing superficial mucosal changes at a high-resolution and
magnification, the investigators will be able to obtain optical images that can be used to
guide endoscopic biopsy and polypectomy. This may foster the selective targeting of
dysplasia/neoplasia, thereby improving diagnostic accuracy.