Holistic Approaches to Depression

Inclusion Criteria:

1. Meets criteria for major depressive disorder (MDD) within the past two years; no
history of bipolar disorder, schizophrenia, or psychotic symptoms in one's lifetime.

2. No current hazardous drug/ alcohol use.

3. Depression symptom severity. Participants must have a Quick Inventory of Depressive
Symptoms (QIDS) score greater than or equal to 8 and less than or equal to 17.

4. Benefit from current treatment. Participants must report at least some benefit from
their current antidepressant.

5. No significant suicidality, defined by a QIDS item #12 score < 2 or PI judgement.

6. Currently taking an antidepressant for depression, at a minimally therapeutic dose.
Participant has been taking an antidepressant for at least 8 weeks.

7. Antidepressant dose has not changed in the 4 weeks prior to study entry; Not planning
to change antidepressant dosage in next 10 weeks.

8. (If in psychotherapy). Therapist and therapy frequency has not changed in the past 6
weeks AND not planning to change it in the next 3 months.

9. Medically cleared for moderate exercise, documented by a note from their primary care
provider.

10. Not pregnant or planning on becoming pregnant in the next year.

11. Naïve to study interventions. Participants cannot have had > 4 single sessions (or >
8 total hours class time) of yoga, other classes in "mindful exercise," (e.g.,
qigong, tai chi), mindfulness based stress reduction, or health education in the past
year or >8 single classes of yoga within the past 2 years of the same. Participants
can not have practiced yoga at least once per week for 8 weeks in a row in the past 5
years.

12. Does not practice meditation at home weekly or more often.

13. Understands English sufficiently well to complete study assessment.

14. Biomarker exclusions. Participants who are taking oral steroids, insulin or oral
hypoglycemic agents, or oral antibiotics, or who refuse blood draws, will not
participate in the biomarker component of the study; however, they may participate in
the rest of the study.