S0927: Omega-3-Fatty Acid Supplements in Treating Muscle and Bone Pain and Stiffness in Pts W/Stage I, II, or III Breast Cancer Receiving Hormone Therapy



Status:Completed
Conditions:Breast Cancer, Cancer, Chronic Pain, Orthopedic
Therapuetic Areas:Musculoskeletal, Oncology, Orthopedics / Podiatry
Healthy:No
Age Range:18 - 120
Updated:4/21/2016
Start Date:February 2012
End Date:March 2014

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S0927: A Randomized Placebo-Controlled Trial of Omega-3-Fatty Acid for the Control of Aromatase Inhibitor-Induced Musculoskeletal Pain and Stiffness In Women With Early Stage Breast Cancer, Phase III

RATIONALE: An omega-3 fatty acid-enriched nutritional supplement may help improve muscle and
bone pain and stiffness caused by hormone therapy in patients with breast cancer.

PURPOSE: This randomized phase III trial is studying omega-3 fatty acid supplements in
treating muscle and bone pain and stiffness in patients with stage I, stage II, or stage III
breast cancer receiving hormone therapy.

OBJECTIVES:

Primary

- To assess whether omega-3-fatty acid as compared to placebo causes a reduction in worst
joint pain and/or stiffness at 12 weeks, as measured by the modified Brief Pain
Inventory (BPI), in women with early-stage breast cancer and aromatase inhibitor
(AI)-associated arthralgia.

Secondary

- To assess the proportion of patients who report improved versus deteriorated joint pain
with omega-3-fatty acid versus placebo.

- To assess the proportion of patients who report improved versus deteriorated joint
stiffness with omega-3-fatty acid versus placebo.

- To assess whether patients receiving omega-3-fatty acid compared to placebo have
decreased analgesic use and increased AI adherence.

- To assess whether patients receiving omega-3-fatty acid compared to placebo have
improved functioning, pain, and stiffness in the knees/hips (as measured by the Western
Ontario and McMaster Universities Osteoarthritis, WOMAC) score.

- To assess whether patients receiving omega-3-fatty acid have improved functioning,
pain, and stiffness in the hands (as measured by the Modified Score for the Assessment
and Quantification of Chronic Rheumatoid Affections of the Hands, M-SACRAH).

- To assess whether patients receiving omega-3-fatty acid compared to placebo have
improved functional quality of life as measured by the Functional Assessment of Cancer
Therapy-Endocrine Subscale (FACT-ES) Trial Outcome Index (TOI).

- To assess whether patients receiving omega-3-fatty acid report changes for the better
versus worse compared to placebo as measured by the Global Rating of Change Scale.

- To identify minimally important change in the WOMAC, M-SACRAH, and the FACT-ES Trial
Outcome Index (TOI) using "a little better" or "a little worse" responses on the
patient-reported global rating of change in joint pain and joint stiffness.

- To assess whether patients receiving omega-3-fatty acid compared to placebo have an
improved lipid profile as measured by triglycerides, HDL, and LDL.

- To assess the toxicity of omega-3-fatty acid compared to placebo in this setting.

- To assess whether there is a difference in serum-free and total estradiol levels before
and after treatment with omega-3-fatty acid compared to placebo.

- To explore whether CYP19A1 genotype correlates with severity of joint symptoms or
predicts response to omega-3-fatty acid. (exploratory)

- To explore changes in hormonal and inflammatory serum biomarkers, such as IL6, TNF-α,
and CRP.

- To assess whether there is a relationship between change in serum docosahexaenoic acid
(DHA) and EPA and resolution of joint symptoms.

- To establish a cohort of patients (placebo group) to better characterize the natural
history of the syndrome.

OUTLINE: This is a multicenter study. Patients are stratified according to prior
osteoarthritis (yes vs no) and prior taxane use (yes vs no). Patients are randomized to 1 of
2 treatment arms.

- Arm I: Patients receive oral omega-3-fatty acid twice daily (BID) or three times daily
(TID) for 24 weeks in the absence of disease progression or unacceptable toxicity.

- Arm II: Patients receive oral placebo BID or TID for 24 weeks in the absence of disease
progression or unacceptable toxicity.

Patients undergo blood sample collection at baseline and at 12 and 24 weeks for biomarker
and DNA analysis.

Patients complete the Brief Pain Inventory Short Form (BPI-SF), the Western Ontario and
McMaster Universities Osteoarthritis (WOMAC) Index, the Modified-Score for the Assessment
and Quantification of Chronic Rheumatoid Affections of the Hands (M-SACRAH), the FACT-ES
Trial Outcome Index, and the Omega-3-fatty acid Dietary Intake questionnaires at baseline
and at 6, 12, and 24 weeks.

DISEASE CHARACTERISTICS:

- Histologically confirmed primary invasive adenocarcinoma of the breast

- Stage I, II, or IIIA disease

- No metastatic disease

- Must have undergone modified radical mastectomy or breast-sparing surgery and
recovered

- Estrogen-receptor positive (ER+) and/or progesterone-receptor positive (PR+)

- Currently taking a third-generation aromatase inhibitor (AI) [e.g., anastrozole
(Arimidex®), letrozole (Femara®), or exemestane (Aromasin®)] for ≥ 90 days prior to
registration with plans to continue for ≥ 180 days after registration

- Must have completed the S092 Brief Pain Inventory (BPI)-Short Form within the past 14
days, and must have a worst pain/stiffness of ≥ 5 on the BPI (item #2) that has
started or increased with AI therapy

PATIENT CHARACTERISTICS:

- Postmenopausal

- Zubrod performance status 0-2

- Willing to submit blood for serum-free estradiol, total estradiol, serum inflammatory
markers (IL6, TNF-α, CRP), DHA and EPA, lipid profile (LDL, HDL, triglycerides), and
DNA analysis (CYP19A1)

- Able to complete study questionnaires in English

- At least 5 years since other malignancy except adequately treated basal cell or
squamous cell skin cancer, in situ cervical cancer, ductal carcinoma in situ of the
breast or adequately treated stage I or II cancer from which the patient is currently
in complete remission

- Patients must not have a known allergy to soy, given that the placebo is suspended in
soybean oil

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

- At least 3 months since prior omega-3 fatty acid supplements and must agree to
refrain from omega-3-fatty acid supplements from sources outside of this study

- More than 28 days since prior investigational agents

- No other medical therapy, alternative therapy, or physical therapy for joint
pain/stiffness within the past 30 days

- Patients must not be on anticoagulation medication (i.e., heparin/warfarin) because
of increased risk of bleeding within 28 days prior to registration

- Patients must not have a history of bone fracture or surgery of the afflicted knees
and/or hands within 6 months prior to registration

- Patients must not be on narcotics within 14 days of registration

- Patients may have received corticosteroid treatment; however, the following criteria
apply:

- Patients must not have received oral or intramuscular corticosteroids within the
28 days prior to registration

- Patients must not have received intra-articular steroids to the study, or any
other, joint within 28 days prior to registration

- Patients must not have received topical analgesics (e.g., capsaicin preparations) to
the study joint or any other analgesics (e.g., opiates, tramadol; with the exception
of nonsteroidal antiinflammatory drugs (NSAIDs) and acetaminophen) within 14 days
prior to registration
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