Comparison of Obesity Alleles Among Diverse Demographic Patients
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 8/25/2018 |
| Start Date: | June 2011 |
| End Date: | January 2019 |
Comparison of Obesity Alleles Among Diverse Demographic Patient Populations Undergoing Bariatric Surgery
This proposal is designed to (1) establish the feasibility of a research strategy for
discovering ethnic differences in the frequency of genotypes in patients after bariatric
surgery and (2) perform a preliminary evaluation of this research strategy. Our goal is to
identify genetic factors that may influence the success of various surgical weight loss
interventions and determine whether these factors are associated with specific patient
populations.
discovering ethnic differences in the frequency of genotypes in patients after bariatric
surgery and (2) perform a preliminary evaluation of this research strategy. Our goal is to
identify genetic factors that may influence the success of various surgical weight loss
interventions and determine whether these factors are associated with specific patient
populations.
Goals:
1. Establish feasibility of obtaining research consent on patients to collect clinical
data, family history, and blood samples.
2. Complete comprehensive genetic analyses on a diverse group of severely obese patients
who have undergone bariatric surgery, specifically the primarily non-Caucasian Bellevue
population and the Caucasian population of Geisinger Health Systems and NYU Langone
Weight Management Program, to help define genetic factors that influence which surgical
interventions work best for which patients. The ultimate aim is to rapidly translate
these discoveries into practical solutions.
Methods and Procedures: The participants of this study are all patients who have undergone
bariatric surgery at Bellevue Hospital, NYU Langone Weight Management Program, and Geisinger
Health System. The investigators have already completed this in 200 patients and plan to
increase enrollment for a total of 2500 patients. The investigators will collect blood
samples on bariatric surgery patients and send the blood to Geisinger for genotyping and
analysis. An extra sample of venous blood (about 4 tablespoons or 40ml) will be collected at
the time of routine postoperative visits. In addition, the investigators will use information
that has routinely been and will be collected during postoperative visits as part of the care
that bariatric patients receive. The investigators will look at the electronic medical record
to obtain the preoperative weights. This includes questionnaires patients complete and the
results of the laboratory tests and other studies.
1. Establish feasibility of obtaining research consent on patients to collect clinical
data, family history, and blood samples.
2. Complete comprehensive genetic analyses on a diverse group of severely obese patients
who have undergone bariatric surgery, specifically the primarily non-Caucasian Bellevue
population and the Caucasian population of Geisinger Health Systems and NYU Langone
Weight Management Program, to help define genetic factors that influence which surgical
interventions work best for which patients. The ultimate aim is to rapidly translate
these discoveries into practical solutions.
Methods and Procedures: The participants of this study are all patients who have undergone
bariatric surgery at Bellevue Hospital, NYU Langone Weight Management Program, and Geisinger
Health System. The investigators have already completed this in 200 patients and plan to
increase enrollment for a total of 2500 patients. The investigators will collect blood
samples on bariatric surgery patients and send the blood to Geisinger for genotyping and
analysis. An extra sample of venous blood (about 4 tablespoons or 40ml) will be collected at
the time of routine postoperative visits. In addition, the investigators will use information
that has routinely been and will be collected during postoperative visits as part of the care
that bariatric patients receive. The investigators will look at the electronic medical record
to obtain the preoperative weights. This includes questionnaires patients complete and the
results of the laboratory tests and other studies.
Inclusion Criteria:
- All patients who have undergone any type of bariatric surgery
Exclusion Criteria:
- Patients who have not had bariatric surgery
We found this trial at
1
site
Click here to add this to my saved trials
