Vitamin D and Functional Outcomes After Total Hip Arthroplasty (THA)
| Status: | Completed |
|---|---|
| Conditions: | Other Indications, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Other |
| Healthy: | No |
| Age Range: | 40 - Any |
| Updated: | 4/2/2016 |
| Start Date: | March 2010 |
| End Date: | March 2015 |
| Contact: | Anas Saleh, MD |
| Email: | saleha@hss.edu |
| Phone: | 212.606.1604 |
The Effect of Serum Vitamin D Level and the Short Term Functional Outcomes After Total Hip Arthroplasty
The investigators would like to evaluate the effect of serum 25-hydroxy vitamin D level on
post-operative short-term functional outcomes after total hip arthroplasty (THA).
Hypothesis: Patients with low serum vitamin D level will have less within-patient
improvement in pre- to 6 week, 1 year, 2 year and 5 year post THA WOMAC scores, SF-36
scores, and performance-based tests(get up and go test and 2 minute walking test) compared
to patients who do not have a low vitamin D levels.
Also, Patients with low serum vitamin D level will have a higher rate of postoperative thigh
pain or periprosthetic fracture.
post-operative short-term functional outcomes after total hip arthroplasty (THA).
Hypothesis: Patients with low serum vitamin D level will have less within-patient
improvement in pre- to 6 week, 1 year, 2 year and 5 year post THA WOMAC scores, SF-36
scores, and performance-based tests(get up and go test and 2 minute walking test) compared
to patients who do not have a low vitamin D levels.
Also, Patients with low serum vitamin D level will have a higher rate of postoperative thigh
pain or periprosthetic fracture.
Vitamin D is an important nutrient to maintain both skeletal and non-skeletal function. In
this study, we have 4 specific aims:
The primary aim of this prospective observational study is to compare the pre- to 6 week, 1
year, 2 year and 5 year post-THA within-patient change in Western Ontario and McMaster
Universities Osteoarthritis Index (WOMAC) scores between patients who have a low
preoperative serum vitamin D level and patients who do not have a low serum vitamin D level.
Low serum vitamin D will be defined as serum 25-hydroxy vitamin D level less than 32 ng/ml.
The secondary aim is to compare the pre- to 6 week, 1 year, 2 year and 5 year post-THA
within-patient change in performance-based tests (get up and go test, 2 minute walking test)
between patients who have a low preoperative serum vitamin D level and patients who do not
have a low serum vitamin D level.
The third aim is to compare the pre- to 6 week, 1 year, 2 year and 5 year post-THA
within-patient change in Short-form 36 health survey (SF-36) scores between patients who
have a low preoperative serum vitamin D level and patients who do not have a low serum
vitamin D level.
The fourth aim is to compare the rate of postoperative fracture or thigh pain between
patients who have a low preoperative serum vitamin D level and patients who do not have a
low serum vitamin D level.
Postoperative thigh pain is defined as pain at the anterolateral aspect of mid thigh which
corresponds to the level of the prosthetic stem tip. Thigh pain is characterized by pain in
the start-up phase, diminishes during movement and is absent at rest.
this study, we have 4 specific aims:
The primary aim of this prospective observational study is to compare the pre- to 6 week, 1
year, 2 year and 5 year post-THA within-patient change in Western Ontario and McMaster
Universities Osteoarthritis Index (WOMAC) scores between patients who have a low
preoperative serum vitamin D level and patients who do not have a low serum vitamin D level.
Low serum vitamin D will be defined as serum 25-hydroxy vitamin D level less than 32 ng/ml.
The secondary aim is to compare the pre- to 6 week, 1 year, 2 year and 5 year post-THA
within-patient change in performance-based tests (get up and go test, 2 minute walking test)
between patients who have a low preoperative serum vitamin D level and patients who do not
have a low serum vitamin D level.
The third aim is to compare the pre- to 6 week, 1 year, 2 year and 5 year post-THA
within-patient change in Short-form 36 health survey (SF-36) scores between patients who
have a low preoperative serum vitamin D level and patients who do not have a low serum
vitamin D level.
The fourth aim is to compare the rate of postoperative fracture or thigh pain between
patients who have a low preoperative serum vitamin D level and patients who do not have a
low serum vitamin D level.
Postoperative thigh pain is defined as pain at the anterolateral aspect of mid thigh which
corresponds to the level of the prosthetic stem tip. Thigh pain is characterized by pain in
the start-up phase, diminishes during movement and is absent at rest.
Inclusion Criteria:
- Patients between the ages of 40 and 100 years old, and are scheduled for primary
total hip arthroplasty with two surgeons (Drs. Sculco and Cornell) at Hospital for
Special Surgery.
- Patients who have a serum 25-OH vitamin D drawn as part of their preoperative
work-up.
Exclusion Criteria:
- Bilateral one-stage total hip replacements
- Patients who required a complex surgical procedure including extensive bone grafting,
osteotomy, extensive soft tissue release, or a need of adjunctive internal fixation
with cables, wires or plate
- Those with serious medical co-morbidities that need adjusted rehabilitation protocol
due to their medical problems
- Those who require immediate postoperative revision due to dislocation, infection or
component malalignment
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