Image-Guided Gynecologic Brachytherapy
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cervical Cancer, Cervical Cancer, Cervical Cancer, Cervical Cancer, Cancer, Cancer, Cancer, Women's Studies |
| Therapuetic Areas: | Oncology, Reproductive |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 7/28/2018 |
| Start Date: | September 2011 |
A Clinical Trial to Evaluate Image-Guided Gynecologic Brachytherapy in the Advanced Multimodality Image-Guided Operating Suite (AMIGO)
Standard therapy for gynecologic cancers involves the use of brachytherapy, also called
internal radiation therapy or implant radiation. The treatment being studied consists of
standard brachytherapy with the additional use of MRI to guide the insertion of radioactive
applicators. The purpose of the study is to find out whether MRI-guided brachytherapy is
practical and beneficial when compared to the standard CT-guided brachytherapy placement. The
investigators are hoping that this MRI procedure will decrease the risk of giving too high a
radiation dose to the bladder or bowel.
internal radiation therapy or implant radiation. The treatment being studied consists of
standard brachytherapy with the additional use of MRI to guide the insertion of radioactive
applicators. The purpose of the study is to find out whether MRI-guided brachytherapy is
practical and beneficial when compared to the standard CT-guided brachytherapy placement. The
investigators are hoping that this MRI procedure will decrease the risk of giving too high a
radiation dose to the bladder or bowel.
The insertion of the brachytherapy applicator will be administered in the Advanced
Multimodality Image-Guided Operating (AMIGO) suite at Brigham and Women's Hospital. Subjects
will undergo an MRI scan in the AMIGO suite ensuring proper placement of the applicator.
Subjects may have an optional FMISO-PET scan.
Subjects will have a follow-up visit including physical exam, pap smear, and MRI of the
pelvis and/or PET scan 90 days after treatment.
Subjects will have a follow-up visit including physical exam, pap smear, and MRI of the
pelvis and/or PET scan 180 days after treatment.
Multimodality Image-Guided Operating (AMIGO) suite at Brigham and Women's Hospital. Subjects
will undergo an MRI scan in the AMIGO suite ensuring proper placement of the applicator.
Subjects may have an optional FMISO-PET scan.
Subjects will have a follow-up visit including physical exam, pap smear, and MRI of the
pelvis and/or PET scan 90 days after treatment.
Subjects will have a follow-up visit including physical exam, pap smear, and MRI of the
pelvis and/or PET scan 180 days after treatment.
Inclusion Criteria:
- Histologically or cytologically confirmed carcinoma of the cervix (Stage I-IVA),
carcinoma of the uterus (Stage IIIB), carcinoma of the vagina (Stage I-IVA), or
carcinoma of the vulva (stage I-IVA)
- Life expectancy > 6 months
- MRI of the pelvis and/or PET-CT within 4 months prior to entering study
Exclusion Criteria:
- Uncontrolled intercurrent illness
- Pacemaker, brain aneurysm clip, inner ear implant, neurostimulator, or metal fragments
in the eye
We found this trial at
1
site
75 Francis street
Boston, Massachusetts 02115
Boston, Massachusetts 02115
(617) 732-5500
Principal Investigator: Akila N Viswanathan, M.D., M.P.H.
Phone: 617-732-6331
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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