Preventing Propofol Injection Pain: Prospective Randomized Trial Comparing Propofol Versus Fospropofol
| Status: | Completed |
|---|---|
| Conditions: | Chronic Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 12/31/2017 |
| Start Date: | August 2010 |
| End Date: | January 2013 |
The purpose of this study is to compare the incidence and intensity of possible pain on
injection as well as patient satisfaction caused by propofol (a lipid based medication);
Lusedra (a water based medication); and the drug combination of propofol with lidocaine (a
local anesthetic commonly used with propofol injection).
injection as well as patient satisfaction caused by propofol (a lipid based medication);
Lusedra (a water based medication); and the drug combination of propofol with lidocaine (a
local anesthetic commonly used with propofol injection).
Propofol (2,6-diisopropylphenol) is one of the most common induction and sedative agents used
today. Properties that make this agent popular include rapid onset and quick recovery.
However, as its use became more widespread, side effects such as pain on injection have
attracted more attention. The incidence of pain on propofol injection is as high as 70 - 90%.
Numerous studies report that more than 50% of patients recall the unpleasant burning
sensation during injection.
Many techniques to minimize pain on injection associated with propofol have been described;
pre-administration of different medications including lidocaine, ketamine, thiopental,
metoclopramide, dexamethasone, ondansetron, and remifentanil have been reported with mixed
success. Some have even tried to use lidocaine with a tourniquet. Others have reported the
use of distraction techniques including counting numbers aloud.
Recently, a solvent mixture of medium chain triglyceride and long chain triglyceride has been
tested for prevention of pain on propofol injection. Lusedra (fospropofol disodium), the
water-soluble prodrug of propofol, does not cause pain on injection as it is water based
medication. Demonstrating the benefit of fospropofol over propofol in patient satisfaction
will improve acceptance by anesthesia providers.
today. Properties that make this agent popular include rapid onset and quick recovery.
However, as its use became more widespread, side effects such as pain on injection have
attracted more attention. The incidence of pain on propofol injection is as high as 70 - 90%.
Numerous studies report that more than 50% of patients recall the unpleasant burning
sensation during injection.
Many techniques to minimize pain on injection associated with propofol have been described;
pre-administration of different medications including lidocaine, ketamine, thiopental,
metoclopramide, dexamethasone, ondansetron, and remifentanil have been reported with mixed
success. Some have even tried to use lidocaine with a tourniquet. Others have reported the
use of distraction techniques including counting numbers aloud.
Recently, a solvent mixture of medium chain triglyceride and long chain triglyceride has been
tested for prevention of pain on propofol injection. Lusedra (fospropofol disodium), the
water-soluble prodrug of propofol, does not cause pain on injection as it is water based
medication. Demonstrating the benefit of fospropofol over propofol in patient satisfaction
will improve acceptance by anesthesia providers.
Inclusion Criteria:
- American Society of Anesthesiologists (ASA) I, II or III.
- Age 18 - 65.
- Both male and female.
- No significant laboratory abnormalities.
Exclusion Criteria:
- Chronic pain patients or patients receiving benzodiazepines or opioids / other
analgesics for control of acute pain will be excluded.
- Patients with known allergies to any of the study drugs, or to soybean oil or egg
lecithin are excluded.
- Women with a positive pregnancy test reported from pre-surgical testing or their
physician's office or who are breast feeding at the time of surgery.
- No emergency patients will be recruited for this study.
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