Glutathione and Health With Post-Polio Syndrome
| Status: | Completed |
|---|---|
| Conditions: | Chronic Pain, Depression, Insomnia Sleep Studies, Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases, Musculoskeletal, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 50 - 65 |
| Updated: | 11/30/-0001 |
| Start Date: | August 2011 |
| End Date: | December 2012 |
| Contact: | Connie Pines |
| Email: | canewman@umich.edu |
| Phone: | 734 764-1454 |
Oral Glutathione and Health Outcomes Among Persons With Post-Polio Syndrome
In this study, people who have symptoms of post polio will take oral glutathione supplements
for three months. Their levels of fatigue, physical function, sleep disturbance, impairment
and emotional distress will be measured with both subjective and objective measures.
Subjects will take a glutathione supplement by mouth for three months after an initial
medical visit, blood draw and physical exam. There are four timepoints during the three
months when subjects will fill out surveys and record food intake and sleep times in diaries
for seven days. They will also wear a small device for seven days, a Sensewear monitor that
records physical activity, body temperature and other measures.
After the fourth timepoint they will return to the medical center for another physical exam
and blood draw. Physicians trained in physical medicine and rehabilitation will be
monitoring the study.
Inclusion Criteria:
- Ability to walk 100 feet with usual assistive devices (ex. cane or walker)
- Having a function score of 18-32 when tested with the IPPS (Index of Post- Polio
Sequelae). This will include people with post-polio symptoms in a very specific
range of severity.
Exclusion Criteria:
- Having another serious medical condition (cancer, multiple sclerosis, etc.)or
inflammatory disease (ie., lupus)
- Currently taking glutathione or other antioxidants
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