Continuous Positive Airway Pressure and Cardiometabolic Risk
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 2/4/2013 |
| Start Date: | March 2011 |
| End Date: | August 2012 |
| Contact: | Seema Kumar, MD |
| Email: | kumar.seema@mayo.edu |
| Phone: | 507-284-3300 |
Impact of Treatment of Sleep Disordered Breathing With Continuous Positive Airway Pressure (CPAP)on Cardiometabolic Risk Markers
Children with sleep disordered breathing will benefit from treatment with Continuous
Positive Airway Pressure (CPAP) or Bi-level Positive Airway Pressure (BiPAP) in terms of
reduction in cardiovascular risk markers and insulin resistance.
Obese children with Moderate to Severe Sleep Apnea would have baseline evaluation of markers
of cardiometabolic risk and insulin resistance. Subjects will then use CPAP for 3 months and
will return for another blood draw for measurement of the markers for cardiometabolic risk
and insulin resistance.
Inclusion Criteria:
1. Body mass index greater than 95th percentile for age and gender
2. Moderate to severe OSA (as defined by an apnea-hypopnea index [AHI] score of ≥5
events per hour).
Only patients who provide informed assent or consent and also have consent from a parent
will be included.
Exclusion Criteria:
1. Predominant central sleep apnea
2. Type 1 Diabetes
3. Type 2 Diabetes
4. Requires use of supplemental oxygen
5. Active infection, cancer, or chronic inflammatory disorder
6. Use of systemic steroids
7. Simultaneous use of peroxisome proliferator-activated receptor (PPAR)-alpha (e.g.,
gemfibrozil, fenofibrate) or PPAR-gamma (e.g., rosiglitazone, pioglitazone)
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