Cardiac Remote Ischemic Preconditioning Before Elective Major Vascular Surgery



Status:Completed
Conditions:Peripheral Vascular Disease
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:July 2011
End Date:September 2015

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Trial Summary
Trial Overview
Inclusion Criteria

Cardiac Remote Ischemic Preconditioning Before Elective Major Vascular Surgery (CRIPES)

Vascular surgery is considered a high-risk operation with an anticipated risk of major
cardiovascular complications in excess of 5%. The occurrence of a cardiovascular
complication after surgery carries a long-term higher mortality risk. The main objective of
this investigation is to reduce the proportion of patients having major cardiovascular
complications during surgery through a clinical protocol of remote preconditioning that is
safe, effective and reproducible.


Inclusion Criteria:

- Eligible patients would be those undergoing elective major vascular surgery at the
Minneapolis VA Medical Center for an expanding abdominal aortic aneurysm, obstructive
carotid disease, and/or chronic limb ischemia during the study period. All patients
must be ≥ 18 years of age and provide written informed consent.

Exclusion Criteria:

- Exclusion criteria include hypertensive crisis, acute coronary syndrome in the
preceding 6 weeks, severe valvular heart disease, peripheral arterial disease of the
upper extremities, manifested by a systolic blood pressure difference greater than 20
mmHg, pregnant women, patients unable to understand the consent process due to mental
illness, advanced malignancy with limited life expectancy (<1 year), and hemodialysis
with a fistula in the upper extremity.
We found this trial at
1
site
Minneapolis VA Medical Center
Minneapolis, Minnesota 55417
?
mi
from
Minneapolis, MN
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