The Effects of Peanuts and Peanut Products on Glucose Control and Vascular Function
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 20 - 50 |
| Updated: | 5/5/2014 |
| Start Date: | August 2011 |
| End Date: | May 2014 |
| Contact: | Jennifer Fleming, M.S., RD |
| Email: | jas58@psu.edu |
| Phone: | 814-863-8056 |
Pilot study data have demonstrated that peanuts ameliorate the postprandial glucose and
insulin response when incorporated into an acute high fat/high glucose meal. However, it is
unclear whether acute consumption of peanuts can also influence vascular function. This
study will therefore evaluate the effects of acute peanut consumption on vascular function,
glycemic control, and plasma lipids. The hypothesis is that that addition of peanuts to a
high fat/high glucose meal will reduce the production of triglycerides, glucose, and improve
endothelial function as measured by flow-mediated dilation (FMD).
insulin response when incorporated into an acute high fat/high glucose meal. However, it is
unclear whether acute consumption of peanuts can also influence vascular function. This
study will therefore evaluate the effects of acute peanut consumption on vascular function,
glycemic control, and plasma lipids. The hypothesis is that that addition of peanuts to a
high fat/high glucose meal will reduce the production of triglycerides, glucose, and improve
endothelial function as measured by flow-mediated dilation (FMD).
Inclusion Criteria:
- 20-50 years of age
- LDL-C below 160 mg/dL
- Triglyceride below 350 mg/dL
- Blood pressure within normal ranges (below 140/90 mmHg)
- Not taking medication for elevated lipids, blood pressure or glucose
Exclusion Criteria:
- Allergies to peanuts or dairy products
- Known intolerance for high fat meals
- History of cardiovascular disease (CVD), kidney disease, diabetes or inflammatory
diseases such as GI disorders and arthritis
- Use of non-steroidal anti-inflammatories or immunosuppressants
- Conditions requiring the use of steroids
- Use of medication or supplements for elevated lipids, blood pressure or glucose
- Donation of blood or plasma during the study
- History of thyroid disease
- Women
- Lactose intolerance
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