Chromoendoscopy for Ulcerative Colitis Surveillance
| Status: | Archived |
|---|---|
| Conditions: | Colitis, Gastrointestinal, Crohns Disease |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
Impact of Chromoendoscopy on the Detection of Neoplasia in Ulcerative Colitis
Long-standing ulcerative colitis is associated with an increased cancer risk.
Chromoendoscopy with dye spraying can detect subtle abnormalities that are not visible with
standard endoscopy. The purpose of this study is to determine if chromoendoscopy with fewer
"targeted biopsies" can replace standard colonoscopy with multiple "random" biopsies.
Patients with ulcerative colitis (UC) are at increased risk for colon cancer. Current
guidelines recommend periodic surveillance colonoscopy in individuals who fulfill certain
high-risk criteria. Endoscopists must perform a high number of biopsies (over 33 per
patient) in order to increase the yield of such procedures. Chromoendoscopy (CE) has the
ability to identify subtle lesions that are otherwise missed by standard endoscopy. Whether
CE can replace standard colonoscopy in the surveillance of patients with UC is unknown.
Comparison: both standard biopsies and targeted biopsies will be obtained during colonoscopy
from patients with UC who are candidates for surveillance colonoscopy. The yield of the two
methods will be compared based on the number of biopsies required to identify one dysplastic
(precancerous) lesion.
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