Occult Paroxysmal Atrial Fibrillation in Patients With Non-cardioembolic Ischemic Stroke of Determined Mechanism

Inclusion Criteria:

1. Age > 50

2. Ischemic stroke, or transient ischemic attack with documented acute brain infarction,
within prior 6 months.

3. Patient does not merit indefinite oral anticoagulation. (Patients requiring temporary
OAC for purposes other than recurrent stroke prevention, such as treatment of a deep
venous thrombosis, are eligible for enrollment if the long-term secondary stroke
preventive strategy is anti-platelet therapy and not OAC).

4. Stroke mechanism is determined to be lacunar stroke, large vessel intracranial
atherosclerosis, large vessel extracranial atherosclerosis, or a combination thereof.

5. Patient has been evaluated with at least a 12 lead EKG and at least one day of
in-patient or out-patient cardiac telemetry, with no detection of AF or atrial
flutter.

6. Detection of AF or atrial flutter would change secondary prevention antithrombotic
strategy (eg to indefinite OAC).

7. Patient receives and successfully activates LifeStar ACT device.

8. Patient or legally authorized representative signs informed consent.

Exclusion Criteria:

1. Known history of AF or atrial flutter.

2. Patient has defibrillator or pacemaker capable of detecting AF.

3. Patient has indication for indefinite OAC.

4. Patient has indefinite contra-indication to OAC. (Patients with temporary
ineligibility for OAC, for example due to the need for invasive medical procedures or
large acute brain infarction, are eligible for enrollment).

5. Stroke due to known cause not listed in inclusion criterion 4.

6. Cardioembolic stroke.

7. Inability to comply with LifeStar ACT monitoring regimen.