The Effects of Sedentarism on Vascular Function, Inflammation, and Insulin Resistance

Inclusion Criteria:

- Healthy subjects: Subjects must be free from any acute, chronic or debilitating
medical conditions. Healthy status will be established on the basis of clinical
history, electrocardiogram, clinical biochemical screening tests of blood and urine,
a physical examination, and where necessary a chest radiograph.

Exclusion Criteria:

- Any active acute or chronic medical problem: Any subject with symptoms of active
illness (e.g., fever, leukocytosis, hypertension) will be excluded from study. The
exclusion criteria will also include history or evidence for psychiatric disorders,
hypertension, diabetes, coronary artery disease (CAD), renal insufficiency, thyroid
disease, alcohol or drug abuse, viral hepatitis, deep venous thrombosis or anemia.
Individuals with a history of psychiatric illnesses or psychiatric disorders will
also be excluded, such as alcoholism, drug dependency including dependency on
tobacco, major mood disorders such as major depression and manic depressive illness,
schizophrenic disorders, anxiety disorders including panic disorder, generalized
anxiety disorder, post traumatic stress disorder, obsessive compulsive disorder,
agoraphobia, claustrophobia, paranoid personality disorder, schizoid personality
disorder, schizotypal personality disorder, borderline personality disorder, and
antisocial personality disorder. In addition, potential subjects with a first order
relative with a history of major depressive illness, manic depressive illness,
schizophrenia, agoraphobia or panic disorder will also be excluded from entry to this
study. Finally, individuals who are unaware of specific psychiatric diagnoses who
have a history of having been treated with antidepressant, neuroleptic medications or
major tranquilizers will be excluded from study. However, a personal history of
limited prior counseling or psychotherapy (e.g., for adjustment reactions) will not
necessarily be exclusionary.