Study of Tissue Samples From Patients With Non-Small Cell Lung Cancer

OBJECTIVES:

- To identify and characterize single nucleotide variations (SNVs) in non-small cell lung
cancer (NSCLC) specimens.

- To identify and characterize structural variations in the genomes of NSCLC specimens.

- To identify and characterize other genomic alterations including, but not limited to,
expression profiling and methylation.

OUTLINE: DNA and RNA extracted from archived specimens are analyzed for single nucleotide
variations, structural variations in the genomes, and other genomic alterations including,
but not limited to, gene expression profiling and methylation. Clinical data related to
disease, treatment, and recurrence from each patient sample is also collected.

- Patient must have been registered to CALGB 140202.

- Tumor histology should be either primary adenocarcinoma or squamous cell carcinoma of
the lung.

- Patients are eligible for this study if their samples from CALGB 140202 are
available.

- All living patients must sign the CALGB 151107 consent form to be eligible for this
trial.