Evoked Retinal Response
| Status: | Completed |
|---|---|
| Conditions: | Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 3/30/2013 |
| Start Date: | July 2011 |
| End Date: | June 2013 |
| Contact: | Harriet O Lloyd, MS |
| Email: | hl2596@columbia.edu |
| Phone: | 2123052703 |
Evoked Visual Response Using Pulsed Ultrasound
Retinitis pigmentosa (RP) is the name given to a group of inherited eye diseases that
affect the retina (the light-sensitive part of the eye). RP causes the breakdown of
photoreceptor cells (cells in the retina that detect light). Photoreceptor cells capture and
process light helping us to see. As these cells breakdown and die, people experience
progressive vision loss. There is no known cure for retinitis pigmentosa. The investigators
have observed that short pulses of focused ultrasound can cause perception of light when
directed to spots on the retinal surface. The investigators propose to conduct a study to
determine if pulsed ultrasound will stimulate the perception of light in the absence of
functional photoreceptors in people with RP
Patients affected by retinitis pigmentosa (RP) and related diseases suffer loss of vision
due to death of photoreceptor cells. The investigators have observed that short pulses of
focused ultrasound can cause perception of light (phosphenes) when directed to spots on the
retinal surface. If this phenomenon is caused by direct stimulation of the retinal nerves,
which seems probable, then it might be possible to use this phenomenon to produce a form of
vision in such patients. The investigators propose to conduct a study of a small cohort of
patients affected by RP to determine if pulsed ultrasound will evoke a perception of light
in the absence of functional photoreceptors.
Inclusion Criteria:
- retinitis pigmentosa
- legally blind in at least one eye
Exclusion Criteria:
- unable to lay down on an exam table
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