Tissue Procurement for Gastric Cancer, Gastrointestinal Stromal Tumors (GIST), Esophageal Cancer, Pancreas Cancer, Hepatocellular Cancer, Biliary Cancer, Neuroendocrine, Peritoneal Mesothelioma, Anal Cancer and Colorectal Cancer in Patients Undergoing Surgery or Biopsy

The purpose of this study is to collect and store normal and malignant tissue from patients
with gastric cancer, GIST, esophageal cancer, pancreas cancer, hepatocellular cancer, biliary
cancer, neuroendocrine, peritoneal mesothelioma, anal cancer and colorectal cancer, an
estimated 50 to 100 of each tumor type. To collect and store blood samples from patients with
gastric cancer, GIST, esophageal cancer, pancreas cancer, hepatocellular cancer, biliary
cancer, neuroendocrine, peritoneal mesothelioma, anal cancer and colorectal cancer. To create
a database for the collected tissue and allow access to relevant clinical information for
current and future protocols. To create tissue microarrays for each gastrointestinal cancer
subtype, namely, gastric cancer, GIST, esophageal cancer, pancreas cancer, hepatocellular
cancer, biliary cancer, neuroendocrine, peritoneal mesothelioma, anal cancer and colorectal
cancer, to facilitate future molecular studies. To grant access to Dr Kindler, Dr. Salgia,
and Dr. Catenacci to this database (as it is being acquired) of the coupled patient tissue
samples (normal and malignant) and relevant clinical information for the investigation of
tyrosine kinases, such as Met and Ron, receptor tyrosine kinase family members, STATs,
paxillin, focal adhesion proteins, cell motility/migration proteins,
tyrosine/serine/threonine kinase family members, related molecules, and downstream targets
implicated in the pathogenesis of GI cancers. Examples of molecular testing include
evaluation of DNA mutation, alternative splice variants, protein expression and
phosphorylation, and immunohistochemistry on samples. These studies will be correlated with
clinical information as stated above.