Identification of Novel Genetic Factors That Contribute to Risk for Breast Cancer

Breast cancer takes its greatest toll on younger women, as it is the leading category of
cancer deaths for women 20-39 years of age. Sadly, survival rates are lowest among women
diagnosed at a young age. This impact is most significant among African-American women who
have the highest incidence and mortality rate among women less than 45 years of age. The goal
of our program is to identify the genetic factors which distinguish breast cancer in younger
women compared to older women.

Women who were diagnosed with invasive breast cancer 40 years of age or younger are invited
to participate. The age at diagnosis is used to determine eligibility, not a woman's current
age. Women who have undergone genetic testing of the BRCA1, BRCA2, p53, pTEN, e-cadherin, or
LKB1 genes are eligible to participate. Young women with breast cancer are asked to: sign a
consent form, submit a sample of blood, release their cancer related records, and answer some
family history questions.

We will use a family based case control approach in our analysis. As such, if a woman's
parents are living, they will be invited to participate as a "comparison" group. The parents
are asked to: sign a consent form, submit a sample of blood, and release any cancer records.

A woman does not have to live in St. Louis to participate. All study related materials can be
mailed directly to the young woman or her parents. There is no expense to the family. All
materials are kept strictly confidential and participation is completely voluntary.

Inclusion Criteria:

- Women diagnosed with invasive breast cancer 40 years of age or younger. If their
parents are living, the parents are also invited to participate, regardless of their
history of cancer.

Exclusion Criteria:

- Women diagnosed with in-situ breast cancer.