Effects of Vitamin D Supplementation During Pregnancy on Clinical Outcomes and Immune Function
| Status: | Completed |
|---|---|
| Conditions: | Other Indications, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 2/4/2013 |
| Start Date: | August 2010 |
| End Date: | June 2013 |
| Contact: | Bryon Jacoby, MD |
| Email: | bryon.jacoby@ucdmc.ucdavis.edu |
| Phone: | (916) 734-6032 |
Assessment of Inflammatory Markers and Pregnancy Outcomes in Vitamin D-Supplemented Women at Risk of Vitamin D Deficiency: A Double-Blind, Randomized Controlled Trial
Researchers at the USDA Western Human Nutrition Research Center and clinicians at UC Davis
Medical Center are currently conducting a study on the effects of vitamin D supplementation
during pregnancy on maternal health and immune function. The investigators believe that
vitamin D supplementation at levels greater than the current recommendation is beneficial
for maternal health during pregnancy. In particular, there is evidence that vitamin D
deficiency during pregnancy puts women at greater risk for diseases like pre-eclampsia,
which may be due to an imbalance in immune function at the placenta. This randomized,
double-blind study is designed to test this hypothesis. Pregnant women who participate in
the study receive either 400 IU or 2,000 IU of vitamin D per day for the duration of their
pregnancy. The investigators will collect blood at three time points during pregnancy (16-20
weeks, 26-28 weeks, 36 weeks gestation) for analysis of immune function and vitamin D
status. The investigators are also collecting data on clinical parameters, such as blood
pressure and glucose tolerance.
Inclusion Criteria:
- Pregnant women
- Less than 20 weeks gestation
- Over 18 years of age
- Able to swallow nutritional supplements
Exclusion Criteria:
- Use of medications known to affect vitamin D metabolism
- Diagnosis of type 1 diabetes
- History of thyroid, renal, or liver disease
- Problems with digestion or absorption
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