Study of Exercise and Heart Function in Patients With Heart Failure and Pulmonary Vascular Disease
| Status: | Completed |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), Cardiology, Pulmonary |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/1/2014 |
| Start Date: | August 2011 |
| End Date: | June 2014 |
| Contact: | Jasmine A Sexton, BS, BAS |
| Email: | sexton.jasmine@mayo.edu |
| Phone: | 507-438-4665 |
Evaluation of Exercise Intolerance and Right Heart Function in Patients With Heart Failure and Pulmonary Vascular Disease
Heart Failure with Preserved Ejection Fraction (HFpEF) and Pulmonary Hypertension (PH) can
be diagnosed noninvasively by Exercise Echocardiography (ExE) and Cardiopulmonary Exercise
Testing (CPX) as compared with gold standard invasive hemodynamic assessment.
be diagnosed noninvasively by Exercise Echocardiography (ExE) and Cardiopulmonary Exercise
Testing (CPX) as compared with gold standard invasive hemodynamic assessment.
- The broad objective of this proposal is to characterize the dynamic changes in
cardiopulmonary mechanics during stress in patients with exertional dyspnea,
establishing a comprehensive multimodality diagnostic approach to the evaluation of
exercise intolerance.
- The specific objective is to prospectively compare established and novel parameters
derived from echocardiography and CPX with simultaneous, gold standard invasive
measures of cardiovascular hemodynamics at rest and with exercise stress to define the
role of noninvasive testing in the diagnostic workup.
- The primary hypothesis is that combined ExE and CPX can noninvasively identify HFpEF.
cardiopulmonary mechanics during stress in patients with exertional dyspnea,
establishing a comprehensive multimodality diagnostic approach to the evaluation of
exercise intolerance.
- The specific objective is to prospectively compare established and novel parameters
derived from echocardiography and CPX with simultaneous, gold standard invasive
measures of cardiovascular hemodynamics at rest and with exercise stress to define the
role of noninvasive testing in the diagnostic workup.
- The primary hypothesis is that combined ExE and CPX can noninvasively identify HFpEF.
Inclusion Criteria:
- exertional intolerance/dyspnea of unknown etiology
- referral to cardiac catheterization laboratory
- undergoing invasive hemodynamic evaluation for clinical purposes
Exclusion Criteria:
- hypertrophic cardiomyopathy
- constrictive pericarditis
- infiltrative myopathy (e.g. amyloid)
- congenital heart disease
- resting LVEF <50%
- > moderate mitral annular calcification
- moderate or greater left-sided valvular stenosis or regurgitation
- prior valve surgery
- basal septal wall motion abnormalities
- >70% epicardial coronary artery stenosis
- right ventricular infarction
- pregnancy
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